Table of content Definition of 3D bioprinting Principle Technology over view Components of 3D bioprinters Types of bioprinters Steps of bioprinting process Applications Challenges Future direction
Definition 3D bioprinting: It is a revolutionary technology that merges 3D printing techniques with biology, which allows the creation of complex, living tissue structures and organs as well . We can say that the 3D bioprinting is the process of creating structures and tissues that imitate the behavior and structure of natural tissues by using bio inks that are made of living cells to print layer by layer structures. By using this technique researchers can study the functions of human body in vitro .
Principle The principle of 3D printing is based on the precise placement of biological components, biochemicals, and living cells in a layer-by-layer fashion with the spatial control of the placement of functional constituents onto the fabricated 3D structure. The process of 3D bioprinting is based on three distinct approaches; biomimicry or biomimetics, autonomous self-assembly, and mini-tissue building blocks.
Technology over view This technology is generally based on the same principle of traditional 3D printers. But in this technique we use bio ink which is composed of living cells. A bioink is any natural or synthetic polymer which is selected for its biocompatible components and favorable properties. A bioink typically supports living cells. characteristics of bio ink Helps in cell adhesion, cell proliferation and cell differentiation during maturation.
Components of 3D bioprinter bioprinters have three major components to them. These are the hardware used, the type of bio-ink, and the material it is printed on (biomaterials).
Types of bioprinters Extrusion based bioprinting Inject based bioprinting Pressure assisted bioprinting Laser assisted bioprinting Stereolithgraphy
Steps of 3D bioprinting Pre bioprinting Bioprinting Post bioprinting
Applications of 3D bioprinting Tissue Engineering Drug Development Screening Toxicology Screening Tissue model for cancer research
Applications of 3D bioprinting
Applications
Applications
Challenges The basic issue in bioprinting are availability of suitable bioinks having high biocompatibility and mechanical strength. The speed of the bioprinting process should be increased to mass-produced biomaterials at a commercially acceptable level as the current speed is slow. Vasculature of tissue constructs is an important challenge in 3D bioprinting as the tissues require continuous oxygen and nutrients. There are some ethical issues with 3D bioprinting as the cost of the method might make it inaccessible to the poor. Because bioprinting is a novel technology, it should be studied sufficiently to ensure it is going to be safe for humans. Personalized 3D printing technology might lead to a serried of regulatory problems to ensure printed product supervision.
Future direction 3D bioprinting is a rapidly developing technology that has the potential to revolutionize the way of disease treatment and injuries. By using 3D printers to create living tissue, scientists can create new treatments for a variety of conditions, including cancer, heart disease, and even spinal cord injuries . In near future we’ll be able to make artificial organs which will prevent the patient from tissue rejection and also prevent people from organ donation or transplant