ABOUT SD RAT

ABOUT SD RAT

1. TRANSLATION OF ANIMAL DOSE INTO HUMAN DOSE AND INTERSTING FACT ABOUT SD RAT Presented by: Jayant kumar MS ( Pharm.) Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research, SAS Nagar(Punjab )

2. Translation Of Human Dose Into Animal Dose HED Animal dose Human Km Animal Km HED = HUMAN EQUIVELENT DOSE Human km A=37 Ch=25 Rat=6 Mouse=3 Rabit =12 G.p .=8

3. BEHAVIORAL STUDY ON RAT Exhausted = animal will see very tired Sluggish = slow moving or inactive animal Somnolent = animal will see sleepy drowsy Rear = raise itself upright on it hind leg

4. Grooming = brush or clean the coat Coprophagy = eating of faeces or dung Normal behavior of animal Leaping Chasing Hudding Climbing Walking Standing Burrowing Nesting Gnowing Foraging retreating BEHAVIORAL STUDY ON RAT

5. THE SPRAGUE DAWLEY RAT Good general model for underlining study :- Human toxicology Reproduction pharmacology Behavioral research Diabetes It is widely used due to its calmness and ability to be handled easily.

6. Life span = up to 3.5 Body wt. female = 250-300g male = 450-520g Birth wt = 5-6 g HR = 330-480 bpm Respiratory rate = 85 breaths per minutes Body temp. = 35.9-37.5 c Blood volume = 50-70ml/kg Urine volume = 3.3 ml/100g bwt /day FACTS ABOUT SD RAT

7. Sexually mature at about 65 days old. Gestation period of the sprague dawley is only 22 days. Litters can consist of up to 12 pups. Pups can be weaned at around 3 weeks and females can begin cycling again only 2-4 days after weaning. The pup’s eyes begin to open around 2 weeks. They begin to eat an adult rat’s diet at around 3 weeks of age.  By 4 weeks they are completely independent. Conted ….

8. These rats are unable to vomit due to the placement of the esophagus as it enters the stomach.  These rats have no gall bladder. Peculiar lung arrangement: the left lung has one lobe, while the right lung has four. Most interestingly, sprague dawley rats produce secretions from their eyes when stressed that contain a pigment which, when dry, has the appearance of dried blood. SOME INTERESTING FACTS ABOUT SD RAT