Active constituent of Turmeric as Anticancer

Active constituent of Turmeric as Anticancer

1. Active constituent of Curcuma longa Linn (Turmeric) Used as Antitumor

2. Synonyms Saffron Indian; Haldi ; Curcuma; Rhizoma curcumae. Biological Source Turmeric is the dried rhizome of Curcuma longa Linn. belonging to family Zingiberaceae. Geographical Source The plant is a native to southern Asia and is cultivated extensively in temperate regions. It is grown on a larger scale in India, China, East Indies and Pakistan.

3. Extraction Add Ethanol 100% Solvent Extraction Method :

4. Chemical Constituents Curcumin , demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC) Eugenol, dihydrocurcumin, azulene, borneol, d-camphene, caprylic acid, cineol, turmerone.

5. Chemically it is 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione or diferuloylmethane It is a member of the diarylheptanoid This class is comprised of two aromatic rings linked by 1,6-heptadiene-3,5-dione moiety Curcumin exists in multiple tautomeric states in which the diketone is stable in the enol state while being easily deprotonated to the keto state Curcumin

6. Chemical structures of keto and enol forms of curcumin

7. Medicinal Activity Antitumor activity Antioxidant activity Antidiabetic activity Hepatoprotective activity Antialzhiemer activity Anti-HIV activity Antivenom activity Anti-inflammatory activity Antibacterial activity Digestive Agent

8. Mechanism of Action Inhibition of constitutively activated targets of PI3'-kinase (AKT,FOXOandGSK3) in T-cell acute lymphoblastic leukemia cells, leading to the inhibition of proliferation and induction of caspase -dependent apoptosis Inhibition of MDM2 oncogen through the transcription factor ETS2 by modulation of the PI3K/ mTOR signaling pathway. Induction of an increase in the protein levels of the pro apoptotic Bcl-2 family members Bax and Bak , which was essential for maximum apoptotic activity

9. Structure Activity Relationship

10. Synthesis