Adenovirus

Adenovirus belongs to the family Adenoviridae
This is a double stranded DNA virus
Does not possess an envelope
Adenovirus is icosahedral in shape
Thus not easily destroyed
It’s name is given as this virus is first isolated from the add noise
But this virus can affect several systems and cause several illnesses
Adenovirus affects respiratory system, gastrointestinal system, genitourinary system and the eye
So this virus has many serotypes

1. Adenovirus

2. Adenovirus Family - Adenoviridae ds DNA Non enveloped Icosahedral Not easily destroyed Many serotypes Affects respiratory, gastrointestinal and genitourinary systems and the eye

3. ln details Adenovirus belongs to the family Adenoviridae This is a double stranded DNA virus Does not possess an envelope Adenovirus is icosahedral in shape Thus not easily destroyed It’s name is given as this virus is first isolated from the add noise But this virus can affect several systems and cause several illnesses Adenovirus affects respiratory system, gastrointestinal system, genitourinary system and the eye So this virus has many serotypes

4. Transmission Close personal contact, such as touching or shaking hands The air by coughing and sneezing Touching an object or surface with adenoviruses on it, then touching your mouth, nose, or eyes before washing your hands Ingestion

5. Respiratory diseases Pharyngitis Serotypes 1,2,3,5,7 Acute respiratory disease Serotypes 4,7,14,21 Pharyngoconjuctival fever Serotypes 3,7 Pneumonia Stereotypes 1,2,3,7

6. GIT infections Acute gastroenteritis Stereotypes 40, 41

7. GU infections Acute haemorrhagic cystitis Stereotypes 11, 21

8. Eye infections Acute follicular conjunctivitis Epidemic keratoconjunctivitis

9. Acute follicular conjunctivitis Cause by serotypes 3, 4, 11

10. Epidemic keratoconjunctivitis Aggressive conjunctivitis and keratitis Pain Photophobia Highly contagious Caused by serotypes 8, 9, 37

11. Acute gastroenteritis Year round prevalence Outbreaks reported in crowded places like hospitals, orphanages Age less than 4 years, more affected Caused by enteric adenoviruses, serotypes 40 & 41

12. Pharyngo-conjunctival fever Conjunctivitis In 1/3 to ½ cases Commonly unilateral, but bilateral in ¼ cases Fever Pharyngitis Pharyngeal erythema & educate may mimic Streptococcal pharyngitis Adenoid enlargement This is a swimming pool associated illness due to inadequate chlorination of water Caused by serotypes 3 & 7

13. Samples collected Eye swabs Nasopharyngeal aspirate Throat swabs

14. Laboratory diagnosis Virus isolation Antigen detection by immunofluorescence PCR

15. Management No antiviral treatment Supportive care

16. Infection control measures Wash your hands often with soap and water Avoid touching your eyes, nose, and mouth with unwashed hands Avoid close contact with people who are sick Stay home when you are sick Cover your mouth and nose when coughing or sneezing Adequate chlorination of water