Aggressive Periodontitis OR MIP (1).pptx

MIP

1. What is AGGRESSIVE PERIODONTITIS

2. Primary features Non-contributory Medical history Rapid attachment loss and bone destruction Familial aggregation

3. SECONDARY FEATURES Microbial deposits inconsistent with severity Elevated proportions of Aggregatibactor actinomycetemcomitans Phagocyte abnormalities Hyper responsive macrophage BURN OUT

4. Gingival responses Severely , acutely inflamed tissue. Suppuration, Ulcerated and Fiery red. Pink, Free of inflammation with / without stippling.

5. TYPES Localized aggressive periodontitis Generalized aggressive periodontitis

6. Localized Aggressive PERIODONTITITS First molar and INCISORS. two teeth apart from them 0.1 to 0.5% prevalence

7. Clinical features Circumpubertal onset rapid Localized molar/ incisor presentation Robust serum antibody response to infecting agents

8. OTHER Features Diastema formation Increasing mobility Sensitivity Deep, dull radiating pain during mastication

9. Reasons of limitation of pd destruction to certain teeth A A evades host response by chemotaxis inhibiting factors, endotoxins, collegenases , leukotoxin. Strong antibody response later on. Antagonist bacteria to AA colonize periodontal tissues AA may loose its leukotoxin producing ability Defect in cementum formation responsible for localization

10. Radiographic finding Arc- shaped bone loss from distal of second premolar to mesial of second molar

11. Generalized Aggressive Periodontitis 0.13 % Prevalence 3 teeth or more apart from molars and incisors. Poor serum antibody response to infecting agents

12. Radiographic findings Severe bone loss 25 to 60 % bone loss

13. RISK FACTORS FOR AGGRESSIVE PERIO Microbiologic factors Immunologic factors Genetic factors Environmental factors

14. Microbiologic factors No Significant clear association was found between Aggressive and AA Bacterial invasion of connective tissue

15. Immunologic factors Display functional defects of PMN , monocytes or both Can be due to bacterial infection or may be genetic High amount of Igg2 in response to AA in LAP

16. Genetic factors Major gene or set of genes play a role Autosomal dominant pattern

17. Environment factors Smoking has more of an impact on general aggressive compared to localized aggressive

18. THE END