AGR Portal WormBase Workshop International Worm Meeting 2017

Alliance of Genome Resources

1. www.alliancegenome.org

2. Now: worm gene

3. Now: fly gene

4. AGR portal Aims A consistent view of model organism data for human geneticists Integrative tools and views not present in individual MOD sites (Eventually) A single portal for all of the MODs Timeline First public release - October 2017 Search Gene report pages Basic information Transcript structures (genome browser) Function (GO annotations) Orthology Disease 2018 and beyond- More data types Phenotype, Expression, Interaction... Integrated views

5. AGR Gene report page

6. AGR Gene report page

7. Orthology

8. Common genome browser

9. Disease Human gene Model Organism gene Name (DO) Subtype Symbol Genomic location Species Symbol Ortholog score Exp. models? Alzheimer's disease ALZHEIMER DISEASE 1 APP 21q21.3 Mouse App 10 108 Rat App 10 343 Frog app 6 - Fish appb 6 - Fly Appl 7 4 Fly Hsap\APP n/a 36 Worm apl-1 7 4 APBB2 4p14-p13 Mouse Apbb2 8 - Frog apbb2 5 - Fish apbb2b 3 - Worm feh-1 6 - ALZHEIMER DISEASE 2 APOE 9q13.32 Mouse Apoe 8 - etc… etc… etc… etc… Integrative views - human disease models

10. Gene Species Gene ontology Disease Expression Phenotype Mutants CDK1 Human + + - + + Cdk1 Rat + + - - - Cdk1 Mouse + - + + + cdk1 Zebrafish + - - + - Cdk1 Fly + + + + + cdk-1 Worm + + + + + CDC28 Yeast + - + + + CDK2 Human + + - - + CDK3 Human + + - - + CDK5 Human + + - + + CDK6 Human + + - + + CDK4 Human + + - + + Integrative views - available data summary

11. Gene Species CDK1 Human Cdk1 Rat Cdk1 Mouse cdk1 Zebrafish Cdk1 Fly cdk-1 Worm CDC28 Yeast Integrative views - comparative gene structure

12. Integrative views - gene ontology

13. Need input! What do you want from the AGR portal?

14. Goodman, Josh Grumbling, Gary Kaufman, Thom Strelets, Victor Thurmond, Jim Bolt, Bruce Davis, Paul Howe, Kevin Kersey, Paul Paulini, Michael Russell, Matt Shafie, Myriam Williams, Gary Balhoff, James Carbon, Seth Dunn, Nathan Lewis, Suzi Miyasato, Stuart Muller, Hans-Michael Mungall, Chris Munoz-Torres, Monica Muruganujan, Anushya Nguyen-Xuan, Jeremy Overton, James Thomas, Paul Bradford, Yvonne Eagle, Anne Fashena, David Frazer, Ken Howe, Doug Kalita, Patrick Mani, Prita Martin, Ryan Paddock, Holly Pich, Christian Ramachandran, Sridhar Ruzicka, Leyla Schaper, Kevin Shao, Xiang Singer, Amy Taylor Moxon, Sierra Toro, Sabrina Van Slyke, Ceri Westerfield, Monte Anagnostopoulos, Anna Baldarelli, Richard Beal, Jonathan Bello, Susan Blake, Judy Blodgett, Olin Bult, Carol Campbell, Jeff Christie, Karen Corbani, Lori Dolan, Mary Drabkin, Harold Frost, Pete Giannatto, Sharon Hale, Paul Hill, David Hutchins, Lucie Kadin, Jim Knowlton, Michelle Law, MeiYee Lewis, Jill McAndrews, Monica Miers, David Motenko, Howie Neuhauser, Steve Ni, Li Recla, Jill Reed, Deborah Richards-Smith, Beverly Richardson, Joel Shaw, David Sitnikov, Dmitry Smith, Cindy Stone, Kevin Tomczuk, Monika Wilming, Laurens Zhu, Sophia Assis, Pedro Binkley, Gail Cherry, Mike Engel, Stacia Hellerstedt, Sage Karra, Kalpana Lang, Olivia MacPherson, Kevin Miyasato, Stuart Nash, Rob Sheppard, Travis Skrzypek, Marek Weng, Shuai Wong, Edith Brodie, Kent De Pons, Jeff Ghiasvand, Omid Hayman, Tom Laulderkind, Stan Petri, Victoria Shimoyama, Mary Smith, Jennifer Thota, Jyothi Tutaj, Marek Tutaj, Monika Wang, Shur-Jen Zacher, Stacy Antonazzo, Giulia Attrill, Helen Brown, Nick Costa, Marta Fexova, Sylvie Jones, Tamsin Larkin, Aoife Marygold, Steven Millburn, Gillian Rey, Alix Staudt, Nicole Urbano, Pepe Crosby, Lynn dos Santos, Gil Emmert, Dave Falls, Kathleen Gramates, Sian Matthews, Beverley Perrimon, Norbert Russo Gelbart, Susan Tabone, Chris Zhou, Pinglei Zytkovicz, Mark Cain, Scott Gao, Sibyl Harris, Todd Nuin, Paulo Stein, Lincoln Wright, Adam Chan, Juancarlos Chen, Wen Grove, Chris Lee, Raymond Li, Yuling Raciti, Daniela Schindelman, Gary Sternberg, Paul Tuli, Mary Ann Van Auken, Kimberly Yook, Karen The Alliance of Genome Resources