Albendazole Tablet

Albendazole is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body. Albendazole is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm

1. Albendazole Presented By : Md. Faysal Id:151-29-760

2. Albendazole Generic Name: Albendazole Dosage Form: Tablet , Suspension Available Strength: 200 mg, 400 mg/Tablet , 200mg/5ml s uspension. No . of Manufacturer: Eighty/80 Brand Leader: Eskayef Bangladesh Ltd . ( Alben DS) Group of Drugs: Anti- anthelmintics

3. Introduction Albendazole is a broad-spectrum oral anthelmintic agent. It is the drug of choice for treatment of hydatid disease and cysticercosis . It is also used in the treatment of pinworm and hookworm, round worm, whip worm, and thread worm infections. Mechanism Of Action of albendazole Blocks glucose uptake Binds with β tubulin & inhibits microtubules polymerization Side Effects Side effects include Epigastric pains, Diarrhoea , Dizziness, Constipation,

4. Contraindication Hypersensitivity to Albendazole Tablet is a contraindication. In addition, Albendazole Tablet should not be used if you have the following conditions : Alcohol Live vaccines Pregnancy Severe renal impairment Including prescription and over-the-counter medicines, vitamins, and herbal products . Praziquantel Cimetidine Drug Interaction Storage Condition Tablet: Store at room temperature and keep away from light. Keep out of the reach of children .

5. Formulation of Albendazole Tablet Ingredients Amount Justification Albendazole 400 mg API Maize Starch 150 mg Binder Mannitol 268.9 mg Diluent Povidone K-30 5 mg Polymer SLS 4 mg Wetting agent Sodium Saccharin 4.1 mg Sweetening agent Croscarmillose Sodium 10 mg Disintegrant Orange Flavor 5.5 mg Flavor Magnesium Stearate 2.5 mg Lubricant Purified Water Q.S Final weight of tablet = 850 mg API ( Albendazole ) = 400 mg Excipients = 450 mg

6. Method The granules are prepared by wet granulation method. Albendazole , maize starch, lactose monohydrate, and SLS were loaded into Rapid Mixer to get a dry mix. The above dry mix was granulated with binder solution and dried in the rapid drier at 60C the granules were mixed with (CCS), sodium saccharin, orange flavour in a granulator for 10 minutes adding lubricant (MS) and Blending and tablet formation by 8 station rotary press tablet compression machine.

7. Required Machineries Dispensing ( weight balance) Sifter Milling equipment(Sieving ) Required Packaging Materials Aluminium and PVC blister sheet, Paper box, Cardboard

8. Product Benefits Cheap, available, more potent, safe medication. Strength are available for different age as child , adult and old age. Product Features Shape : circular or round shape tablet Half life: 8-12 hours Shelf life: 5 years Solubility: soluble in methanol  ,chloroform, ethyl acetate insoluble in water Protein binding: 70 % Melting point: 208 to 210 °C (406 to 410 °F )