Alpha glucosidase inhibitor

antidiabetic drug

1. alpha glucosidase inhibitor Antidiabetic drug

2. Mechanism of action

3. Mechanism of action

4. Pharmacological effects Postprandial glucose levels is reduced both in normal and diabetic subjects, so creating an insulin sparing effect . The efficacy of the drugs is small . Hypoglycemia does not occur even in overdosage .

5. Pharmacokinetics Oral bioavailability: acarbose 2%; miglitol >90 % Elimination : miglitol > 90% by the kidney

6. Contra-indications and cautions Inflammatory bowel disease Gastrointestinal conditions worsened by gas or distension Renal disease

7. Therapeutic uses Type II diabetes as monotherapy or in combination with sulfonylureas or insulin. As monotherapy in elderly patients or in patients with predominantly postprandial hyperglycemia. Note : if hypoglycemia occurs when administered with insulin or sulfonylureas, oral administration of sugars other than glucose is ineffective .

8. alpha glucosidase inhibitors