Alteplase

alteplase description

1. ALTEPLASE BY:- ZAINI SULTAN KHAN BSC BT II YEAR

2. PATENT INFO

3. DESCRIPTION Alteplase   is a thrombolytic drug. Alteplase   injection is used to dissolve  blood clots that have formed in the blood vessels. It is a tissue plasminogen activator used to treat acute myocardial infarctions.

4. METHOD OF PREPAPARATION Alteplase  is an enzyme that occurs naturally in man and causes blood clots to dissolve . It is a man- made  protein manufactured by recombinant DNA technology. It is known as tissue plasminogen activator (TPA ), and is made  by ovarian cells from the Chinese hamster.

5. MECHANISM OF ACTION Alteplase was the first recombinant tissue-type plasminogen activator. Recombinant tissue plasminogen activator binds to fibrin in thrombus. Entrapped plasminogen is converted to plasmin by the plasminogen activator. Plasmin conversion initiates local fibrinolysis .

6. SIDE EFFECTS nausea vomiting low blood pressure dizziness mild fever allergic reactions

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