Antacid

Antacid Analysis

1. COMPARITIVE ANALYSIS OF ANTACIDS Presented by – Rushikesh M. Kale Roll no. – 27751 Guide – Dr. K. B. Gabhane VIDYABHARTI COLLEGE OF PHARMACY, AMARAVATI 444602, 2019-2020

2. INDEX INTRODUCTION IDEAL CHARECTERISTICS MECHANISM TYPES OF ANTACID USES CASE STUDY RESULT & CONCLUSION REFRENCES Batch : 2019-2020 2

3. Introduction An Antacid is any substance , generally a base or basic salt, which neutralizes stomach acidity. They are used to relive acid indigestion, upset stomach ,sour stomach and heartburn Some An Antacid are a class (group) of medicine which help to neutralized the acid content of your stomach An Antacid : Aluminum Hydroxide. Sodium Carbonate This comes in various different brand name and are available as tablets liquids Batch : 2019-2020 3

4. Batch : 2019-2020 4

5. Batch : 2019-2020 5

6. Batch : 2019-2020 6

7. Batch : 2019-2020 7

8. Batch : 2019-2020 8

9. CALCIUM CARBONATE Calcium carbonate is widely available at natural inorganic compound , also known as chalk limestone Calcite is most stable polymorph of calcium carbonate. it is transparent to opaque Carbonate is found frequently in geologic setting and constitutes an enormous carbon reservoir. It occurs as aragonite , calcite and dolomite as significant constituents of calcium cycle. Calcium carbonate is mainly used in construction industry, as a calcium supplement for gastric antacid. Batch : 2019-2020 9

10. STRUCTURE HO Ca O OH Batch : 2019-2020 10

11. Quantative analysis of calcium carbonate Abstract Fourier Transform Infrared Spectroscopy (FT-IR) was used successfully for the simultaneous quantitative analysis of calcium carbonate phases (calcite, aragonite, vaterite ) in ternary mixtures. From the FT-IR spectra of pure calcite, aragonite and vaterite powders with KBr , the absorptivities , a, of the absorption bands at 713 cm1 for calcite, 745 cm1 for vaterite , 713 and 700 cm1 for aragonite, were determined. In order to overcome the absorption band overlapping a set of equations based on Beer’s law was developed. The detection limits were also established and found to be 1.1/104 mg calcite per mm2 of pellet at 713 cm1, 3.6/104 mg aragonite per mm2 of pellet at 700 cm1, Keywords: FT-IR; Calcite; Aragonite; Vaterite ; Quantitative analysis; Synthetic calcium carbonate Batch : 2019-2020 11 CASE STUDY

12. The speciation of carbonate-bicarbonate in aquatics systems A fundamental process that has been studied extensively recently Alice et al. Reported the hydration behavior of CO Using Near Edge X-ray Absorption Fine Energy Spectroscopy. Oliver and Davis observed that in an aqueous system about 10%of the Bicarbonate decomposed to carbon dioxide and carbonate at 25 8C according to following equation 2 HCO CO2+CO32- Introduction Batch : 2019-2020 12

13. Experimental Instrumentation All spectra were recorded from 4000/400 cm1, using the EQUINOX 55 ( Brucker ) FT-IR spectrometer. The IR spectra were recorded and stored using a spectroscopicsoftware (OPUS, Version 2.0). The crystal size was measured by using the Mastersizer S (Malvern Instruments, England). Batch : 2019-2020 13

14. Reagents ammonium carbonate calcium nitrate sodium carbonate potassium nitrate sodium hydrogen carbonate standard sodium hydroxide Purified water Batch : 2019-2020 14

15. Batch : 2019-2020 15 INSTRUMENTATION

16. Batch : 2019-2020 16

17. Results and discussion The selection of the appropriate bands for the quantitative analysis was a difficult task since there is a strong overlapping. The absorption bands chosen for the quantitative analysis of a ternary mixture were the 713 cm1 for calcite, the 700 and 713 cm1 for aragonite, and the 745 cm1 for vaterite . Batch : 2019-2020 17

18. Batch : 2019-2020 18

19. Conclusions A new methodology, based on the use of FT-IR, was used successfully for the simultaneous quantitative determination of anhydrous calcium carbonates crystal phases. The absorptivities for the absorption bands of the polymorphs used in the analytical technique were established and the respected detection limits were determined. The proposed methodology allows a direct simultaneous quantitative determination of calcium carbonates phases as opposed to Raman spectroscopy where only relative ratios can be determined. Batch : 2019-2020 19

20. Thank you! Batch : 2019-2020 20