Antacids

antacids

1. ANTACIDS SEMINAR – INORGANIC MEDICINAL CHEMISTRY PREPARED BY- SHREE RAM THAKRAL SUBMITTED TO – MS. MANISHA UID- 16BPH1054 B.PHARMACY UIPS,CHANDIGARH UNIVERSITY GHARUAN PB.

2. Antacid Our stomach produce dilute hydrochloric acid (HCL) helps in digestion to our food without harming the stomach ,Sometimes the excess of acid is produced in the stomach which cannot treat with the dilute hydrochloric acid (HCL)that will harm us in the stomach, to prevent from acidity we use the bases called as “ Antacid ”. Antacid reversibly reduce or block the secretion of acid by gastric cells to reduce acidity in the stomach.

3. About Antacid Chemical substances which remove the excess acid and raise the pH to an appropriate level in stomach are called “Antacid”. Acid gastric is a very common aliment associated with digestion and is caused by an excess of Hydrochloric Acid(HCl) in the gastric juice. The commonly used Antacids are; Magnesium Hydroxide. Magnesium Carbonate. Magnesium Trisilicate. Aluminium Hydroxide gel. Sodium Bicarbonate. Aluminium Phosphate.

4. Components of Antacid Antacids are weak bases that are used to neutralize excess stomach acid Most antacids are weak inorganic bases Common examples include : CaCO 3 ( CALCIUM CARBONATE ) NaHCO 3 ( SODIUM BICARBONATE ) Al(OH) 3 ( ALUMINIUM HYDROXIDE) Mg(OH) 2 ( MAGNESIUM HYDROXIDE ) MgO and Mg(OH) 2 (Milk of Magnesia)

5. Indications when we take Antacid When heart burn is there then we take Antacid to reduce the heartburn. Treatment with antacids alone is symptomatic and only justified for minor symptoms . A typical feeling of restlessness. Indigestion. Feeling of nausea (wanting to throw up) and a ctual vomiting.

6. Causes Of Excessive Release Of Acids In The Stomach Alcohol Consumption. Eating Certain Foods. Smoking. Certain Drugs i.e. Aspirin. Stress.

7. Reaction of Antacid Antacids react with HCl in the stomach Some common antacid reactions include: CaCO 3 + 2 HCl  CaCl 2 + H 2 O + CO 2 NaHCO 3 + HCl  NaCl + H 2 O + CO 2 Al(OH) 3 + 3 HCl  AlCl 3 + 3 H 2 O Mg(OH) 2 + 2 HCl  MgCl 2 + 2 H 2 O MgO + 2 HCl  MgCl 2 + H 2 O

8. Uses of Antacid It bring down the percentage of Acidity in our Stomach and prevent mucus lining in the stomach. It prevent from HEART BURN It also prevent from the ULCER (damage to lining of stomach wall, resulting in loss of tissues and inflammation).

9. Side Effect Of Antacid Magnesium Compounds may cause diarrhea Aluminum Compounds may cause constipation and they also may interfere with the adsorption of phosphates in the formation of bones Calcium compounds containing may also increase calcium output in the urine, which might be associated with kidney stones. Sodium : Increased intake of sodium may lead to heart failure and many renal diseases.