Anti d

Anti-D drugs is used in Rh compatibiity of blood

1. Introduction Anti D is a medicine given by intramuscular injection that is used to prevent the immunological condition known as Rh diseases. The medicine is a solution of IgG Anti D antibodies that out any fetal Rh D positive erythrocyte which have entered the maternal blood stream from fetal circulation before the maternal immune system can react to them.

2. Generic Name : Anti D Trade Name: Rho GAM Rho Phyloc Win RhoSOF Available Forms: Injection(IM) – 300mcg vial 50mcg vial Injection(IV) – 120mcg, 300mcg,500mcg, 1000mcg, 3000mcg.

3. Indication and Dosage * Rh exposure after abortion, miscarriage, ectopic pregnancy or child birth. *Blood bank determines fetal packed RBC volume entering patients blood one vial 1GIM is given IM. *To prevent Rh antibody formation after abortion or miscarriage. Consult transusion unit one 1GIM micro dose vial IM.

4. Rh exposure after abortion amniocentesis after 39 weeks of gestation or other manipulation past 34 weeks. -120mcg 1GIV given IV or IM at 28 weeks. -Incompatible blood transfusion. -600mcg iv every 8hours or 1200mcg in every 12 hours until total dose given. -Idiopathic thrombocytopenic purpura in Rho(D) antigen- positive adult Initially 50mc g/kg IV as single dose on divided into two doses an seperate .

5. Mechanism of Action mechanism of action not completely known. Suppress action of antibody response and formation of anti D anti bodies in Rh -D negetive . D negetive person expose to Rh positive blood. Rho(D) immunoglobulin IV may block platelet destruction in Rho(D) antigen positive adults.

6. Contraindication Contraindicated in Rho(D) positive or D positive patient and in the ose previously immunized to Rho(D) blood factor. Patient with anaphylactic or severe systemic reaction to human globulin. Use extreme caution when giving drug to paients with immunoglobulin A deficiency.

7. Interaction Drug – drug lve viruses vaccines – may interfere with response. Postpond immunization for 3 month.

8. Adverse Reaction *Central nervous system; -Fever -Head ache -Chills -Dizziness -Weakness *Skin; -Discomfort at injection site *Other; -Anaphylaxis

9. Nursing Considerations Patient with immunoglobulin A deficiency may develop immunoglobulin A antibodies and have anaphylactic reaction prescribe must high benefit of treatment against risk of hypersensitivity reaction before giving. Obtain history of alleries and reaction to immunization keep epinephrine 1:1000 ready to treat anaphylaxis. Immediately after delivery send a sample of neonates cord blood to laboratory for testing and cross matching confirm if mother is Rho(D) OR Dpositive . This immune serum provides passive fetal blood during pregnancy and prevents formation of maternal antibody which would indanger future. Postpan volination with live virus vaccine for 3 months after administration or Rho(D) Ig .