Antigenic Properties of the Rabies Virus.pptx

Antigenic Properties of the Rabies Virus. Helps in vaccine preparation.

1. Antigenic Properties of the Rabies Virus Overview of key antigenic proteins and epitopes of the rabies virus. Chandan B S, 108, 210201298

2. What are Antigens? Antigens are molecules that trigger an immune response Antigens are usually proteins or polysaccharides on the surface of pathogens like viruses that are identified by the immune system Binding between antigens and antibodies is highly specific The immune system can recognize millions of unique antigens and produce matching antibodies against each one Some antigens can elicit memory B cells Memory B cells remember past infections and allow for a faster immune response upon re-exposure Antigens play a key role in adaptive immunity by marking pathogens for destruction and facilitating immunological memory.

3. Rabies virus is a neurotropic virus that causes inflammation of the brain in humans and mammals. Understanding the antigenic properties of the rabies virus glycoprotein is critical for developing effective vaccines and diagnostics.

4. Rabies Virus Structure Rabies Virus Structure Model 3D model of rabies virus structure showing glycoprotein spikes protruding from the surface.

5. Key Antigenic Properties Glycoprotein G Glycoprotein G mediates viral binding to the host cell receptor and is the main target for neutralizing antibodies. Nucleoprotein N Nucleoprotein N forms a ribonucleoprotein complex that protects the viral genome and is highly immunogenic. Phosphoprotein P Phosphoprotein P binds to nucleoprotein N and supports viral RNA transcription and replication. Matrix protein M Matrix protein M lines the inner viral envelope and promotes viral assembly and budding.

6. Glycoprotein-G and Nucleocapsid are the major antigens of rabies. There are a few differences between the two as follows:

7. Vaccination Glycoprotein G Glycoprotein G is a key antigenic component of the rabies virus that elicits neutralizing antibodies. Post-exposure prophylaxis Inactivated rabies vaccines are highly effective for post-exposure prophylaxis if administered promptly after a bite from a rabid animal. Pre-exposure prophylaxis Pre-exposure prophylaxis with inactivated rabies vaccines provides protection against rabies before potential virus exposure.

8. Conclusion Understanding the antigenic structure of the rabies virus is crucial for developing effective vaccines and treatments. Further research should focus on identifying conserved antigenic sites that can elicit a protective immune response. Developing monoclonal antibodies that target key antigenic sites may also hold promise for post-exposure prophylaxis.

9. Thank you