antiseborrhics keratolytics and melanizing agents

dermatopharmacology

1. KERATOLYTICS ANTI-SEBORRHEICS & MELANIZING AGENTS

2. KERATOLYTICS Dissolve intercellular substance in horny layer of skin Epidermal cells swell, soften & desquamate SALICYLIC ACID,RESORCINOL,UREA

3. KERATOLYTICS SALICYLIC ACID 10-20% sol in alcohol or propylene glycol for dissolving corns . Polypylene glycol?

4. KERATOLYTICS RESORCINOL Antiseptic,antifungal,keratolytic 3-10% for eczema,seborrheic dermatitis, ringworm

5. KERATOLYTICS UREA 5-20% in cream & ointment base Ichthyosis,lichen planus Concurrently with topical steroid?

6. KERATOLYTICS SALICYLIC ACID 10-20% RESORCINOL 3-10% UREA 5-20%

7. DANDRUFF???

8. ANTI-SEBORRHEICS Seborrheic dermatitis- face ,trunk, scalp(dandruff) Pityrosporum ovale Emotional , genetic,local factors

9. ANTI-SEBORRHEICS SELENIUM SULFIDE ZINC PYRITHIONE CORTICOSTEROIDS IMIDAZOLE ANTIFUNGALS SULFUR, COAL TAR,AMMONIATED MERCURY RESORCINOL SALICYLIC ACID

10. ANTI-SEBORRHEICS SELENIUM SULFIDE 2.5% lotion or shampoo Antiproliferative,antikeratolytic,fungicidal More than 50% -relapse on discontinuation.

11. ANTI-SEBORRHEICS ZINC PYRITHIONE Weekly shampoo-1% ‘Reduce’ epidermal turnover, dandruff With ketoconazole

12. ANTI-SEBORRHEICS CORTICOSTEROIDS Lotion-massage in scalp Relapse rates high Atopy ,poor healing, purpura ...

13. ANTI-SEBORRHEICS IMIDAZOLE ANTIFUNGALS KETACONAZOLE (KTZ)-200mg/day for 4 weeks 2% shampoo/cream/scalp gel Good – excellant results without much S/E

14. ANTI-SEBORRHEICS SELENIUM SULFIDE 2.5% ZINC PYRITHIONE 1% CORTICOSTEROIDS IMIDAZOLE ANTIFUNGALS SULFUR, COAL TAR,AMMONIATED MERCURY RESORCINOL SALICYLIC ACID

15. MELANISING AGENTS Increase sensitivity to solar radiation Repigmentation of vitiliginous areas Stimulate melanocytes & induce proliferation

16. MELANISING AGENTS PSORALEN METHOXSALEN TRIOXSALEN

17. MELANISING AGENTS PSORALEN Ammi majus Furocoumarins – photoactivation stimulate melanocytes & induce proliferation

18. Ammi majus

19. MELANISING AGENTS METHOXSALEN & TRIOXSALEN Synthetic psoralens Sensitize skin Topical & oral Short plasma t1/2 ; max skin sensitization 1-2 hrs ;lasts for 8 hrs.

20. MELANISING AGENTS

21. MELANISING AGENTS TOPICAL Solution or ointment On well defined vitiliginous lesion 1 min exposure to sunlight Occluded by bandage or sunscreen ointment Under supervision of physician.

22. MELANISING AGENTS ORAL THERAPY “In alternate days after 2 hrs of 0.3-0.6mg/kg 15 min exposure to sunlight gradually increasing to 30 min.” Normally pigmented areas should be protected

23. MELANISING AGENTS PSORALEN METHOXSALEN TRIOXSALEN

24. Keratolytics salicylic acid,resorcinol , urea Anti- seborrheics selenium sulfide , zinc pyrithione , corticosteroids imidazole antifungals . Melanizing agents- Psoralen , methoxsalen , trioxalen

25. THANK YOU