Antiulcer drugs ppt.pptx

This ppt is fully informative for Antiulcer Drugs

1. ANTI - ULCER DRUGS BENGAL SCHOOL OF TECHNOLOGY DEBARGHYA TAPADAR M.PHARM PHARMACOLOGY 1 st YEAR,2 nd SEM 2022-2024

2. INTRODUCTION OF P E P T I C U L C E R An Ulcer is ….. Erosion in the lining of the stomach or the first part of the small intestine, an area called the duodenum. U l c e r s da m ag e th e m u c o s a o f th e a li m entar y t r a c t , w h ich e x t e nd s throu g h th e m u s c u l a r i s m u c o s a i nt o th e s u b m u c o s a o r d e eper . Ulcers that form in the stomach are called gastric ulcers; in the duodenum, they are called duodenal ulcers. Both types are referred to as peptic ulcers.

3. P E P T I C U L C E R

4. EITIOLOGY H.pylori Drugs such as NSAID’S Lifestyle Factors Severe emotional or physiological stress Having Family history

5. PATHOGENESIS OF PEPTIC ULCER DISEASE A G G RE S S I V E FACTORS 𝗈 A c i d 𝗈 P e p s i n 𝗈 H e l i c o b a c t e r p y l o r i 𝗈 N S A I D S DEFENSIVE FACTORS Prostaglandins M u c o s a l b l o o d f l o w M u c o u s g e l l a y e r HCO3 E p i t h e l i a l j u n c t i o n s R e g e n e r a t i o n o f t h e e p i t h el i a l layer E p i d e r m a l g r o w t h f a c t o r

6. PHYSIOLOGY

7. CLASSIFICATION OF ANTIULCER AGENT 1 .Reduction of gastric acid secretion H 2 a n t i h i s t a m i n i c s : Cimetidine, ranitidine, famotidine, roxatidine P r o t o n p u m p i n h i b i t o r s : Omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole, dexrabeprazole A n t i c h o li n e r g i c d r u g s : Pirenzapine , propantheline, oxyphenomium P r o s t a g l a n d i n a n a l o g u e : misoprostol 2. Neutralization of gastric acid Systemic : Sodium bicarbonate, sodium citrate Non systemic: Magnesium hydroxide, mag trisilicate, aluminium hydroxide gel, magaldrate, calcium carbonate 3.Ulcer protective : Sucralfate, colloidal bismuth subcirtrate 4.Anti H-pylori drugs: Clarithromycin, metronidazole, amoxicillin, tinidazole, tetracycline

8. DRUGS USED IN PEPTIC ULCER

9. Regulation of Gastric Acid Secretion

10. Reference 1.Piper DW. A comparative overview of the adverse effects of antiulcer drugs. Drug safety. 1995 Feb;12:120-38. 2. Rodríguez LG, Jick H. Risk of gynaecomastia associated with cimetidine, omeprazole, and other antiulcer drugs. BMJ. 1994 Feb 19;308(6927):503-6. 3 . Katsura Y, Nishino S, Inoue Y, Tomoi M, TAKASUGI H. Studies on Antiulcer Drugs. II. Synthesis and Antiulcer Activities of Imidazo [1, 2-a] pyridinyl-2-alkylaminobenzoxazoles and 5, 6, 7, 8-Tetrahydroimidazo [1, 2-a] pyridinyl Derivatives. Chemical and pharmaceutical bulletin. 1992 Feb 25;40(2):371-80. 4 . Berndt ER, Bui LT, Lucking- Reiley DH, Urban GL. The roles of marketing, product quality, and price competition in the growth and composition of the US antiulcer drug industry. InThe economics of new goods 1996 Jan 1 (pp. 277-328). University of Chicago Press.