Apoptosis_robins.MCQs.pptx.bydr.sana.khurram

MCqs on apoptosis

1. MCQs on Apoptosis Based on Robbins Pathology Your Name / Institution (Optional)

2. What is apoptosis? a) Accidental cell death b) Programmed cell death c) Necrotic cell death d) Unregulated cell division **Answer: b) Programmed cell death**

3. Which of the following is NOT a characteristic of apoptosis? a) Cell shrinkage b) Inflammatory response c) Chromatin condensation d) Formation of apoptotic bodies **Answer: b) Inflammatory response**

4. The intrinsic pathway of apoptosis is regulated by which organelle? a) Nucleus b) Lysosome c) Mitochondria d) Golgi apparatus **Answer: c) Mitochondria**

5. Which of the following proteins is anti-apoptotic? a) Bax b) Bak c) Bcl-2 d) Caspase-3 **Answer: c) Bcl-2**

6. In the extrinsic pathway of apoptosis, activation occurs through: a) Fas-FasL binding b) Mitochondrial cytochrome c release c) DNA fragmentation d) Endoplasmic reticulum stress **Answer: a) Fas-FasL binding**

7. Which enzyme family is directly responsible for the execution of apoptosis? a) Caspases b) Kinases c) Phosphatases d) Cyclins **Answer: a) Caspases**

8. How does apoptosis differ from necrosis? a) Apoptosis causes inflammation, necrosis does not b) Apoptosis is energy-dependent, necrosis is not c) Apoptosis leads to cell swelling, necrosis leads to shrinkage d) Apoptosis causes plasma membrane rupture, necrosis does not **Answer: b) Apoptosis is energy-dependent, necrosis is not**

9. A mutation in which gene commonly leads to resistance to apoptosis in cancer cells? a) TP53 b) BRCA1 c) MYC d) RAS **Answer: a) TP53**

10. Excessive apoptosis is associated with which condition? a) Cancer b) Autoimmune diseases c) Neurodegenerative disorders (e.g., Alzheimer’s) d) Chronic inflammation **Answer: c) Neurodegenerative disorders (e.g., Alzheimer’s)**

11. A deficiency of Fas signaling is most likely to result in: a) Autoimmune diseases b) Neurodegeneration c) Liver cirrhosis d) Cancer metastasis **Answer: a) Autoimmune diseases**