APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptx

CONTENT:
Definition
Types of niosome
Application of niosome
Application of niosome in cosmetic
References
DEFINITION :
Niosomes are a novel drug delivery system , in which the medication is encapsulated in a vesicle, composed of a bilayer of non – ionic surface active agents and hence the name niosomes.
Niosomes also called as nonionic surfactant vesicles or NSVs .

Nios = non ionic surfactant
Somes = vesicles
The niosomes are very small, and microscopic in size. Their size lies in the nanometric scale
Niosomes are synthetic microscopic vesicles consisting of an aqueous core enclosed in a bilayer consisting of cholesterol and one or more nonionic surfactants.
Vesicles are prepared from self assembly of hydrated non ionic surfactants molecules.
TYPES OF NIOSOMES:
According to the nature of lamellarity :
Small Unilamellar vesicles (SUV) 25 – 500 nm in size.
Large Unilamellar vesicles (LUV) 0.1 – 1μm in size
Multilamellar vesicles (MLV) 1-5 μm in size.

According to the size :
Small Niosomes (100 nm – 200 nm)
Large Niosomes (800 nm – 900 nm)
Very large Niosomes (2 μm – 4 μm)
OTHER TYPE OF NIOSOMES
Proniosomes
Aspasomes
Vesicles in Water and Oil System (v/w/o)
Bola - niosomes
Discomes
Deformable niosomes or elastic niosome
APPLICATION OF NIOSOMES:
A) Ophthalmic Drug Delivery
B) Leishmaniasis
C) Carrier for hemoglobin
D) Delivery of peptide drugs
E)Targeting to bioactive agents
Transdermal delivery of drugs through niosomes and proniosomes
G) Other Application

1. APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM Presented By : Guided By : Tanvi Mhashakhetri Dr. P.S. Gangane M.Pharm Pharmaceutics Associate Professor II Semester Department of Pharmaceutics Dadasaheb Balpande College Of Pharmacy Besa , Nagpur – 440037 2022-2023 1

2. CONTENT Definition Types of niosome A pplication of niosome Application of niosome in cosmetic References 2

3. DEFINITION Niosomes are a novel drug delivery system , in which the medication is encapsulated in a vesicle, composed of a bilayer of non – ionic surface active agents and hence the name niosomes . Niosomes also called as nonionic surfactant vesicles or NSVs . Nios = non ionic surfactant Somes = vesicles The niosomes are very small, and microscopic in size. Their size lies in the nanometric scale . 3

4. Niosomes are synthetic microscopic vesicles consisting of an aqueous core enclosed in a bilayer consisting of cholesterol and one or more nonionic surfactants. Vesicles are prepared from self assembly of hydrated non ionic surfactants molecules. Structure of Niosome 4

5. TYPES OF NIOSOMES According to the nature of lamellarity : Small Unilamellar vesicles (SUV) 25 – 500 nm in size. Large Unilamellar vesicles (LUV) 0.1 – 1 μ m in size Multilamellar vesicles (MLV) 1-5 μ m in size. 5

6. According to the size : Small Niosomes (100 nm – 200 nm) Large Niosomes (800 nm – 900 nm) Very large Niosomes (2 μ m – 4 μ m) OTHER TYPE OF NIOSOMES Proniosomes Aspasomes Vesicles in Water and Oil System ( v/w/o) Bola - niosomes Discomes Deformable niosomes or elastic niosome 6

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8. APPLICATION OF NIOSOMES   8 A) Ophthalmic Drug D elivery From ocular dosage form like ophthalmic solution, suspension and ointment it is difficult to achieve excellent bioavailability of drug due to the tear production, impermeability of corneal epithelium, non-productive absorption and transient residence time. But niosomal and liposomal delivery systems can be used to achieve good bioavailability of drug. Example : Opthalmic Drug Delivery Acetazolamide Gentamycin Reduce intraocular Pressure

9. 9 B ) Leishmaniasis It is a type of parasitic disease to the liver and spleen cells in which the infecting organism resides. These are used for the treatment of diseases in the organs of the reticuloendothelial system in which the infecting organism resides. Example : Anti-infective Agent Sodium Stibogluconate Increase  level of antimony for treatment of  Visceral leshminiasis

10. 10 C ) Carrier for hemoglobin Niosomes used as hemoglobin carriers. Dispersion of niosomes reveals an overlapping visible spectrum of free hemoglobin . Compared to non-encapsulated hemoglobin , the dissociation curve can be modified as these vesicles are permeable to oxygen and hemoglobin .

11. 11 D) Delivery of peptide drugs The oral delivery of 9-desglycinamide and 8-arginine vasopressin in an in vitro intestinal loop model was investigated, and stability of peptide significantly increased. E . Targeting to bioactive agents i . To reticulo -endothelial system The reticulo -endothelial system (RES) cells take the vesicle ideally. The absorption of niosome by the cell is also achieved through the circulating serum factors known as opsonins , which makes them apparent . Niosomal in Oral Drug Delivery Insulin prepared with Niosomes Increases gastro intestinal tract absorption

12. 12 Nevertheless this localized medicine build-up was used for the treatment of tumors that are likely to metastases the liver and spleen for a parasitic liver infection . ii. To the organs other than RES These carriers help to guide antibodies to specific location in the body. Immunoglobulins seem to quickly bind on the lipid surface, providing a natural means for the drug carriers targeting. Most cells can identify and bind different carbohydrate determinants, which can be used in the framework of direct actions.

13. 13 F) Transdermal delivery of drugs through niosomes and proniosomes The major drawback of transdermal drug delivery is the slow penetration through the skin. Transdermal drug delivery system of niosomes and proniosomes has led to increasing the penetration rate thereby enhancing therapeutic efficiency and bioavailability of the drug . Example : Transdermal Drug Delivery Keterolac with Span 60 Increases Bioavailability and Therapeutic effect

14. 14 G) Other Application Sustained release Sustained release action of niosomes can be applied to drugs which have low therapeutic index and have low solubility with water since those could be maintained in the circulation via niosomal encapsulation . ii. Localized drug action Drug delivery through niosomes is one of the approaches to achieve localized drug action, since their size and low penetrability through epithelium and connective tissue keeps the drug localized at the site of administration .

15. APPLICATION OF NIOSOMES IN COSMETIC Niosomes of N-acetyl glucosamine are prepared due to its potential in the delivery of hydrophilic and hydrophobic drugs in topical form and improved penetration into the skin. Prepared formulations improved the extent of drug localized in the skin, as needed in hyperpigmentation disorders . Elastic niosomes showed increased permeation through the skin which will be beneficial for topical anti-aging application . 15

16. 16 Example : Lancome Anti-ageing cream suitable for skin moisturising and tanning products . Niosomes were prepared as possible approach to improve the low skin penetration and bioavailability shown by conventional topical vehicle for minoxidil .

17. 17 Meloxicam is a non-steroidal anti-inflammatory agent (NSAIDs), has been widely used in thetreatment of rheumatoid arthritis, osteoarthritis.

18. REFERENCES 18 S.P. Vyas , R.K. Khar , Targeted and Controlled Drug Delivery , N ovel Carrier System, page no. 249-279. Sanjay K. Jain and N.K. Jain Controlled and Novel Drug Delivery System, page no. 213 – 225. Durga Bhavani and Veera Lakshmi a brief review of enhancing transdermal delivery of drug Recent advances of non-ionic surfactantbased nano -vesicles ( niosomes and proniosomes ) page no. 15-18.

19. THANK YOU 19