Arosol Dosage Form

pharmaceutical Dosage Form

1. Presented by :-
Md. Hamidul Kowsar
Dept. of Pharmacy
State University of Bangladesh
Aerosol Dosage form

2. Word Origin :
the Greek word “αήρ” (aeros) means Air and the English word
“sol”, of Latin origin, which means solution.
Definition :
Pharmaceutical aerosols are pressurized dosage forms
containing one or more active ingredients
intended for administration orally or nasally as fine solid
particles or liquid mists through the pulmonary airways, nasal
passages or oral cavity.
Example : nebulizers, DPIs
Aerosol Dosage form

3. Route of administration

Topical :Lidocaine aerosol, Benzocaine aerosol spray (anesthetics )
Oral :Ipratropium oral inhalation, Albuterol Oral Inhalation ( COPDs)
 Nasal : Budesonide Nasal Spray (allergies )
 Rectal : pramoxine aerosol foam

Aerosol Dosage form

4. An aerosol formulation consists of the product
concentrate, the propellant, Container, Valve .
The product concentrate is the active ingredient
such as antioxidants, surface-active agents,
solvents, and efficacious product
A propellant is a chemical with a vapor pressure
greater than atmospheric pressure at 40°C
(105°F). Example : chlorofluorocarbons,
hydrocarbons,hydrofluorocarbons etc.
Aerosol Dosage form

5. Solution system / Two phase system
Water based system / Two components or Three
components system
Suspension / Dispersion system
Foam system / Emulsion system
Aqueous stable foams
Non-Aqueous stable foams
Quick Breaking foams
Thermal foams
Intra nasal aerosols
Compressed gas systems
Types of aerosol
system
Aerosol Dosage form

6. Aerosols are easy and convenient to apply
The onset of action is faster
The dispersion of medicament is very good.
It also can avoid the first pass metabolism.
Metered valve can release the contents in controlled
and uniformly.
Sterility can be for sterile product
For Inhalation purpose a fine mist of the drug is
produced.
Irritation can be reduced
Advantages
Aerosol Dosage form

7. Aerosols are cost effective .
Disposal empty aerosol containers are difficult.
Due to volatility of the propellant can irritate the
injured skin.
Aerosol packs must away from temperature and fire.
Sometimes propellants may cause toxic reations.
Disadvantage
Aerosol Dosage form

8. Physical stability of aerosol dispersion can be
increased by :
Control of moisture content. (<300ppm)
Reduction of initial particle size to less than 5 um.
Adjustment of density of propellant and suspensoid so
that they are equalized.
Use of dispersing agent
Use of derivatives of active ingredients with minimum
solubility in propellant system.

9. Physical stability of a dispersed system depends on rate
of agglomeration of the suspensoid.
Agglomeration is acceleration at elevated temp. and it is
also affected by particle size of drug (1-5u, never >50u).
Isopropyl myristate and mineral oil are used to reduce
agglomeration .
Surfactants of HLB value less than 10 are utilized for
aerosol dispersions
Surfactants are effective in a concentration of 0.01 to 1
%.
Aerosol Dosage form

10. Thanks to
All