Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)

Atarax (Generic Hydroxyzine Hydrochloride Tablets) reduces activity in the central nervous system and also acts as an antihistamine that reduces the effects of natural chemical histamine in the body. It is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Hydroxyzine tablets are used as a sedative to treat anxiety and tension. Hydroxyzine may also be used short-term to treat anxiety or to help you feel sleepy/relaxed before and after surgery. Hydroxyzine is also used to treat allergic skin reactions such as hives or contact dermatitis.

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Atarax (Generic Hydroxyzine Hydrochloride Tablets) reduces
activity in the central nervous system and also acts as an
antihistamine that reduces the effects of natural chemical
histamine in the body. It is an antihistamine and works by
blocking a certain natural substance (histamine) that your
body makes during an allergic reaction. Hydroxyzine tablets
are used as a sedative to treat anxiety and tension.
Hydroxyzine may also be used short-term to treat anxiety or
to help you feel sleepy/relaxed before and after surgery.
Hydroxyzine is also used to treat allergic skin reactions such
as hives or contact dermatitis.

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Active Ingredient
The active ingredient contained in Atarax tablets is
Hydroxyzine Hydrochloride. Each tablet contains 10 mg or
25 mg of Hydroxyzine Hydrochloride.

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Chemical Structure
The structure of Hydroxyzine Hydrochloride is given below:

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Atarax Tablets are manufactured by Dr. Reddy's
Laboratories Limited, India in the strengths of 10 mg and 25
mg.
(Website: https://www.drreddys.com/ )

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Hydroxyzine Hydrochloride Tablets – Brand Names
Hydroxyzine Hydrochloride tablets are
available under various drug trade names
that include Atarax, Vistaril, A-Rex, Adzin,
Atamax and Hydroze.

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Uses of Atarax Tablets
Atarax (Generic Hydroxyzine Hydrochloride Tablets) is used to help
control anxiety and tension caused by nervous and emotional conditions.
It can also be used to help control anxiety and produce sleep before
surgery. This medicine is also used to relieve the symptoms of an allergic
reaction (eg, hives, itching skin) caused by chronic urticaria, and atopic
and contact dermatoses).
Hydroxyzine is an antihistamine. It works by preventing the effects of a
substance called histamine, which is produced by the body.
The effectiveness of Hydroxyzine as an antianxiety agent for long term
use, that is more than 4 months, has not been assessed by systematic
clinical studies.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Atarax Tablets Dosage

The dosage of Atarax tablets (Generic Hydroxyzine
Hydrochloride Tablets) is given below:
For symptomatic relief of anxiety and tension associated with
psychoneurosis and as an adjunct in organic disease states in which anxiety
is manifested:
Adults, 50 mg to 100 mg in divided doses; children under 6 years, 50 mg daily
in divided doses; children over 6 years, 50 mg to 100 mg daily in divided doses.
For use in the management of pruritus due to allergic conditions such as
chronic urticaria and atopic and contact dermatoses and in histamine-
mediated pruritus:
Adults, Starting dose of 25mg at night increasing as necessary to 25mg three
or four times daily.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Atarax Tablets Contraindications
Atarax is contraindicated in patients with a hypersensitivity to Hydroxyzine
Hydrochloride, Cetirizine, other Piperazine derivatives, Aminophylline or
Ethylenediamine, or any other component of this medication.
Atarax (Generic Hydroxyzine Hydrochloride Tablets) is contraindicated in
patients with history of QT prolongation and/or torsade de pointes, including
congenital long QT syndromes; history of cardiac arrhythmias; significant
electrolyte imbalance (hypokalaemia, hypomagnesium); significant bradycardia;
family history of sudden cardiac death; concomitant use of other QT/QTc-
prolonging drugs, or of CYP3A4/5 inhibitors.
Atarax is also contraindicated in asthmatics who have previously experienced a
serious anti-histamine induced adverse bronchopulmonary effect, porphyria and
in early (first trimester) pregnancy.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Storage Instructions

Atarax (Generic Hydroxyzine Hydrochloride
Tablets) have to be stored at controlled room
temperature i.e. from 20°C to 25°C (68°F to
77°F) with excursions permitted between 15°
to 30°C (59° to 86°F).
Keep this as well as all other medicines away
from children and pets.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Warnings

Hydroxyzine has been associated with prolongation of the QT interval on
the electrocardiogram. During post-marketing surveillance, there have
been cases of QT interval prolongation and torsade de pointes in patients
taking Hydroxyzine.
Due to its sedative properties, use of Hydroxyzine tablets must be avoided
in severe liver disease due to an increased risk of coma, and in patients
with hepatic failure due to possibility of hepatic encephalopathy.
Atarax should be used with caution in patients with impaired renal
function. It is uncertain whether the drug may accumulate or have other
adverse effects in such patients.
Hydroxyzine is not recommended in elderly patients because of a decrease
of hydroxyzine elimination in this population as compared to adults and
the greater risk of adverse reactions (e.g. anticholinergic effects)

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Warnings

Because of its potential antimuscarinic actions, Atarax should be used with
caution in patients suffering from angle-closure glaucoma, urinary
retention, prostatic hyperplasia, or pyroduodenal obstruction.
Caution is required in patients suffering the following conditions: seizure
disorders including epilepsy, myasthenia gravis, dementia, decreased GI
motility, bladder outflow obstruction, stenosing peptic ulcer, patients with
breathing problems (e.g. emphysema, chronic bronchitis), increased
intraocular pressure, hyperthyroidism, cardiovascular disease,
hypertension.
Dosage adjustments may be necessary if Atarax is used simultaneously
with other CNS depressants or with drugs having antimuscarinic
properties.
The concomitant use of alcohol and Hydroxyzine tablets must be avoided.

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Warnings

Treatment with this medicine should be stopped for one week before skin testing
for allergy is undertaken, and for 96 hours prior to a methocholine test.
Children and the elderly are more susceptible to side-effects.
Patients should be warned of impaired judgement and dexterity.
Atarax could be associated with an increased risk of heart rhythm disorder which
may be life threatening. Patients must inform their doctor if they have any heart
problems or are taking any other medicines, including medicines obtained
without prescription.
While taking Atarax, patients must seek immediate medical attention in case they
experience heart problems such as palpitations, trouble breathing, loss of
consciousness. Treatment with this medicine must be discontinued immediately.
It is not known whether this drug is excreted in human milk. Since many drugs
are so excreted, Hydroxyzine should not be given to nursing mothers.

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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Side Effects
Side effects of Hydroxyzine Hydrochloride (Atarax tablets) may include
the following:
Skin and Appendages: Oral Hydroxyzine Hydrochloride is associated with fixed
drug eruptions in postmarketing reports. Side effects reported with the
administration of Hydroxyzine Hydrochloride are usually mild and transitory in
nature.
Anticholinergic: Dry mouth.
Central Nervous System: Drowsiness is usually transitory and may disappear in
a few days of continued therapy or upon reduction of dose. Involuntary motor
activity including rare instances of tremor and convulsions have been reported,
usually with doses considerably higher than those recommended. Clinically
significant respiratory depression has not been reported at recommended doses.
Cardiac System: QT prolongation, Torsade de Pointes.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Side Effects
Side effects of Hydroxyzine Hydrochloride (Atarax tablets) may include
the following:
In postmarketing experience, the following additional undesirable effects
have been reported:
Body as a Whole: Allergic reaction.
Nervous System: Headache.
Psychiatric: Hallucination.
Skin and Appendages: Pruritus, rash, urticaria.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Atarax Tablets Overdose
The most common manifestation of Hydroxyzine Hydrochloride
(Atarax tablets) overdosage is hypersedation. Other reported signs
and symptoms were convulsions, stupor, nausea and vomiting.
As in the management of overdosage with any drug, it should be
borne in mind that multiple agents may have been taken.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Treatment of Atarax Tablets Overdose
If vomiting has not occurred spontaneously, it should be induced.
Immediate gastric lavage is also recommended.
General supportive care, including frequent monitoring of the vital signs
and close observation of the patient, is indicated. Hypotension, though
unlikely, may be controlled with intravenous fluids and Levarterenol or
Metaraminol.
Do not use Epinephrine as Hydroxyzine counteracts its pressor action.
There is no specific antidote. It is doubtful that hemodialysis would be of
any value in the treatment of overdosage with Hydroxyzine. However, if
other agents such as barbiturates have been ingested concomitantly,
hemodialysis may be indicated. There is no practical method to quantitate
hydroxyzine in body fluids or tissue after its ingestion or administration.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
Atarax Tablets During Pregnancy
Hydroxyzine Hydrochloride (Atarax tablets) has been
classified by the US FDA as Pregnancy Category C.
Hydroxyzine hydrochloride, when administered to the
pregnant mouse, rat, and rabbit, induced fetal
abnormalities in the rat and mouse at doses substantially
above the human therapeutic range.
Clinical data in human beings are inadequate to establish safety
in early pregnancy. Until such data are available,
Hydroxyzine Hydrochloride Tablets (Atarax) is
contraindicated in early pregnancy.
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Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets)
For more details on
Atarax Tablets click here
Atarax Tablets (Generic Hydroxyzine Hydrochloride Tablets) by
Dr. Reddy's Laboratories Limited, India.
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