Azithromycin

azithromyicin definition , uses , mechanism of action , drug interactions , pharmacokinetics , contraindications

1. pOWEred by , Poojitha modepalli AZITHROMYCIN

2. Generic name : azithromycin Brand name : azasite , azithromycin 3 day dose pack , azithromycin 5 day dose pack , zithromax , zithromax TRI-PAK , zithromax Z -PAK , Z max Drug class : macrolides

3. WHAT IS AZITHROMYCIN? Azithromycin is an antibiotic Azithromycin is used to treat different types of infections caused by the bacteria , such as respiratory infections , skin infections , ear infections, eye infections and sexually transmitted diseases Azithromycin may also be used for purposes not listed in medical guide Mech of action – inhibit RNA dependent protein synthesis

4. PHARMACOKINETICS Route of administration – oral Bioavailability – approximately 37 % Metabolism – hepatic Excretion – biliary Drug elimination is biphasic with Half life – 5 days DOSE- 500mg a day for 3-10 days

5. SIDE EFFECTS MOST COMMON EFFECTS Nausea ,Vomiting , Diarrhea ,Pain in abdomen LESS COMMON EFFECTS Heart palpitations , acid reflux , dizziness , headache, fatigue , vaginitis,skin rashes SERIOUS EFFECTS Liver damage( in liver patients) , heart rhythm changes ( people who take heart medications and low blood potassium) , serious allergic conditions

6. DRUG INTERACTIONS There are 327 drugs which interact with azithromycin categorized as 71 major , 235 moderate and 21 minor interactions (you can check all these interactions in the website https://www.drugs.com ) Most common interactions are nelfinavir , warfarin , digoxin , colchicine , phenytoin , antacids that contain magnesium or alluminium

7. CONTRA INDICATIONS and THERAPEUTIC USES Contraindicated in patients with known hypersensitivity to azithromycin , or any other macrolide and in hepatic diseases. Use with caution in renal failure Therapeutic uses of azithromycin is bronchitis , pneumonia , std , lungs , sinuses , skin, throat and reproductive organs

8. REFERENCES https://www.drugs.com https://www.medicalnewstoday.com https://www.webmd.com https://www.pediatriconcall.com https://www.medlineplus.gov