Barrett’s esophagus.pptx a brief discription

Summary in Barrett's esophagus

1. Barrett’s esophagus Presented by – ALOK KUMAR YADAV ROLL NO. 14

2. INDEX INTRODUCTION ASSOCIATED RISK FACTORS PATHOGENESIS SIGN AND SYMPTOMS DIAGNOSIS MANAGEMENT

3. INTRODUCTION Barrett esophagus is a complication of chronic GERD that is characterised by a intestinal metaplasia within the esophageal squamous mucosa and is associated with an increased risk of cancer. Also called as – Barrett syndrome/ Columnar Lined Lower Oesophagus

4. Associated risk factors 10% cases of symptomatic GERD 2% general population More common in white males ( 40-60 yrs ) Obese population

5. pathogenesis DYSPLASIA

6. MORPHOLOGY Red velvety mucosa extending upward from the gastroesophageal junction. Normal squamous epithelial cell changes into goblet cell .

7. Sign and symptoms Frequent and longstanding heartburn Dysphagia Hematemesis Pain under the breastbone Weight loss

8. Diagnostic approaches ENDOSCOPY ( e sophago -gastro- duodenoscopy ) BIOPSY( presence of goblet cell is seen )

9. management Surveillance by periodic endoscopy with biopsy. PPI’S and NSAIDS Esophagectomy Mucosal resection Photodynamic therapy endoscopic mucosectomy

10. Prevention

11. SUMMARY Barrett esophagus develops in patient with chronic GERD and Represents columnar metaplasia of the esophagial squamous mucosa Barrett esophagus is a risk factor for development of esophageal carcinoma

12. References Pathologic basis of disease by ROBBINS AND COTRAN tenth edition volume 2 . NATIONAL INSTITUTE OF HEALTH ( niddk.nih.gov) Image courtsy – PINTEREST

13. Thank you