basic Gastrointestinal Bleeding aug 24-1.ppt

basic Gastrointestinal Bleeding aug 24-1.ppt

1. Gastrointestinal Bleeding

2. Case…
Hassan is 45 y/o saudi gentleman,
presents to ED at KKUH early morning,
C/O vomiting blood.
How would you approach?
How would you manage?

3. Gastrointestinal Bleeding
PERSPECTIVE
Epidemiology
o relatively common problem
orequires early consultation and hospital
admission.

4. Gastrointestinal Bleeding
oMortality rate for GI bleeding is approximately
10%.
oDiagnostic modalities have improved much
more than therapeutic techniques.

5. Gastrointestinal Bleeding
GI bleeding
ois often easy to identify
…….when there is clear evidence of vomiting
blood or passing blood in the stool.
omay be subtle,
………with signs and symptoms of
hypovolemia, such as dizziness, weakness,
or syncope.

6. Gastrointestinal Bleeding
oManagement approach depends on whether
the hemorrhage is located in the proximal or
the distal segment of the GI tract (i.e., upper
or lower GI bleeding).
oThese segments are anatomically defined by
the ligament of Treitz in the duodenum.

7. Gastrointestinal Bleeding
Lower GI bleeding (LGIB)
oaffects a smaller portion of patients
ofewer hospital admissions than UGIB.

8. Gastrointestinal Bleeding
oOccur in persons of any age.
oMost commonly affects people in their 40s
through 70s.
oMost deaths in patients older than 60 years.
oUGIB is more common in men than in women
(in a 2 : 1 ratio)
oLGIB is more common in women.

9. Gastrointestinal Bleeding
oSignificant UGIB requiring admission is more
common in adults.
oLGIB requiring admission is more common in
children.

10. Gastrointestinal Bleeding
DIAGNOSTIC APPROACH
Differential Considerations
oPeptic ulcer disease
ogastric erosions
ovarices
three fourths of
adult patients
with UGIB.
80% of adults
with LGIB.
oDiverticulosis
oangiodysplasia

11. Gastrointestinal Bleeding
oEsophagitis
oGastritis
opeptic ulcer disease
oinfectious colitis
oinflammatory bowel disease
most common
causes of UGIB
most
common
causes of
LGIB.
In children,

12. Gastrointestinal Bleeding
Meckel’s diverticulum
& intussusception
oAt all ages, anorectal abnormalities are the
most common cause of minor LGIB.
most common cause
of massive LGIB in
children younger
than 2 years of age

15. Gastrointestinal Bleeding
oNo source of bleeding is identified
in approximately 10% of patients
with GI bleeding.

16. Gastrointestinal Bleeding
oIn abdominal aortic grafts pt with with GI
bleeding, the possibility of aortoenteric fistula
should be considered
oPrompt surgical consultation in the ED
should be obtained if this is suspected,
because bleeding can be massive and fatal.

17. Gastrointestinal Bleeding
Rapid Assessment and
Stabilization
oMost patients with GI bleeding
are easy to diagnose by history
+/- physical exam

18. Gastrointestinal Bleeding
oIf hemodynamically unstable should
undergo rapid evaluation and resuscitation.
oshould be undressed quickly with
placement of cardiac and oxygen
saturation monitors.
osupplemental oxygen should be given as
needed.

19. Gastrointestinal Bleeding
oAt least two large-bore (minimum 18-
gauge);
oSend samples for
oCBC, for hg, plat, hematoc.
oCoagulation profile
otype and screen or type and crossmatch
ocrystalloid resuscitation should be
initiated.

20. Gastrointestinal Bleeding
oNS 2-L bolus in adults or 20 mL/kg
in children until the patient’s vital
signs have stabilized or the patient
has received 40 mL/kg of
crystalloid in an adult or 60 mL/kg
as a child.

21. Gastrointestinal Bleeding
oIf remain unstable give type O, type-specific,
or cross matched blood, depending on
availability.
oPersistently unstable patients should receive
immediate consultation with a
gastroenterologist for UGIB and with a
surgeon for LGIB.

22. Gastrointestinal Bleeding
History
In 50%
oPatients typically complain of vomiting
red blood or coffee grounds–like material,
or passing black or bloody stool.
oHematemesis (vomiting blood) occurs
with bleeding of the esophagus, stomach,
or proximal small bowel.

23. Gastrointestinal Bleeding
History
oHematemesis may be bright red or
darker (i.e., coffee grounds–like) as
a result of the conversion of
hemoglobin to hematin or other
pigments by hydrochloric acid in the
stomach.

24. Gastrointestinal Bleeding
oThe color of vomited or aspirated blood from
the stomach does not differentiate between
arterial and venous bleeding.
oMelena, or black tarry stool, will result from
the presence of approximately 150 to 200
mL of blood in the GI tract for a prolonged
period.

25. Gastrointestinal Bleeding
oMelena is seen in approximately
o70% of patients with UGIB
oone third of patients with LGIB.
oBlood from the duodenum or jejunum must
remain in the GI tract for approximately 8
hours before turning black.

27. Gastrointestinal Bleeding
oOccasionally, black stool may follow bleeding
into the lower portion of the small bowel and
ascending colon.
oStool may remain black and tarry for
several days, even though bleeding has
stopped.

28. Gastrointestinal Bleeding
Hematochezia, or bloody stool (bright red or
maroon)
omost often signifies LGIB
oCould be due to a brisk UGIB with rapid transit
time through the bowel in 10 to 15% of patients.
oa more proximal source of significant bleeding
must be excluded before assuming the bleeding
is from the lower GI tract.

29. Gastrointestinal Bleeding
oApproximately two thirds of patients with
LGIB present with red blood from bleeding
per rectum.
oSmall amounts of red blood (5 mL) from
rectal bleeding, such as bleeding due to
hemorrhoids, may cause the water in the
toilet bowl to appear bright red.

30. Gastrointestinal Bleeding
DDX
oBright red stools also can be seen after
ingestion of a large quantity of beets
oHemoccult testing would be negative and the
patient also will report pink colored water in
the toilet bowl.

31. Gastrointestinal Bleeding
Important qs
oduration and quantity of bleeding
oassociated symptoms
oprevious history of bleeding
ocurrent medications,
oalcohol
oNSAID ASA
oallergies
oassociated medical illnesses
oprevious surgery

32. Gastrointestinal Bleeding
symptoms of hypovolemia
…..dizziness, weakness, or loss of
consciousness, most often after standing up.
oOther nonspecific complaints include
dyspnea, confusion, and abdominal pain.

33. Gastrointestinal Bleeding
oRarely an elderly patient may present with
ischemic chest pain precipitated by
significant anemia due to a GI bleed.
oOne in five patients with GI bleeding may
have only nonspecific complaints.

34. Gastrointestinal Bleeding
oThe history is of limited help in predicting the
site or quantity of bleeding.
oPatients with a previously documented GI
lesion bleed from the same site in only 60%
of cases.

35. Gastrointestinal Bleeding
oGross estimates of blood loss based on the
volume and color of the vomitus or stool are
inaccurate.

36. Gastrointestinal Bleeding
Physical Examination
oVital signs and postural changes in heart rate
and blood pressure are insensitive and
nonspecific, with the exception of significant,
sustained heart rate increase and hypotension.

37. Gastrointestinal Bleeding
oAll patients hypotensive and tachycardic
should be assumed to have a significant
hemorrhage.

38. Gastrointestinal Bleeding
oNormal vital signs do not exclude a
significant hemorrhage
opostural changes in heart rate and blood
pressure may occur in individuals who are
not bleeding

39. Gastrointestinal Bleeding
ogeneral appearance
ovital signs
omental status (including restlessness)
oskin signs (e.g., color, warmth, and moisture to
assess for shock, or presence of lesions such
as telangiectasia, bruises, or petechiae to
assess for vascular diseases or hypocoagulable
states)
opulmonary and cardiac findings
oabdominal examination

40. Gastrointestinal Bleeding
oFrequent reassessment is important because
a patient’s status may change quickly.

41. Gastrointestinal Bleeding
oRectal Examination Rectal and stool
examinations are often key to making or
confirming the diagnosis of GI bleeding.
oThe finding of red, black, or melenic stool
early in the assessment is helpful in
prompting early recognition and management
of patients with GI bleeding.

42. Gastrointestinal Bleeding
oThe absence of black or bloody stool,
however, does not exclude the diagnosis of
GI bleeding.
oRegardless of the apparent character and
color of the stool, occult blood testing is
indicated.

43. Gastrointestinal Bleeding
Ancillary Testing
Tests for Occult Blood
oThe presence of hemoglobin in occult
amounts in stool is confirmed by tests such as
( Hemoccult, HemaPrompt).
oStool tests for occult blood may have positive
results 14 days after a single, major episode of
UGIB.

44. Gastrointestinal Bleeding
False-positive
oassociated with the ingestion of
ocertain fruits (e.g., cantaloupe, grapefruit, figs),
ouncooked vegetables (e.g., radish, cauliflower,
broccoli)
ored meat
omethylene blue, chlorophyll, iodide, cupric
sulfate, and bromide preparations.

45. Gastrointestinal Bleeding
False-negative
ouncommon but can be caused by bile or
ingestion of magnesium containing antacids
or ascorbic acid.
oTests to evaluate gastric contents for occult
blood (e.g., Gastroccult) can be unreliable
and should not be used for this purpose.

46. Gastrointestinal Bleeding
Clinical Laboratory
oThe initial hematocrit may be misleading in
patients with preexisting anemia or
polycythemia.

47. Gastrointestinal Bleeding
oChanges in the hematocrit may lag
significantly behind actual blood loss.
orapid infusion of crystalloid in nonbleeding
patients also may cause a decrease in
hematocrit by hemodilution.

48. Gastrointestinal Bleeding
ohemoglobin concentration of 8 g/dL or less
(hematocrit <25%) from acute blood loss
usually require blood therapy.
oAfter transfusion and in the absence of
ongoing blood loss, the hematocrit can be
expected to increase approximately 3% for
each unit of blood administered (hemoglobin
level increases by 1 mg/dL).

49. Gastrointestinal Bleeding
oThe PT should be used to determine whether
a patient has a preexisting coagulopathy.
An elevated PT may indicate
ovitamin K deficiency
oliver dysfunction
owarfarin therapy
oconsumptive coagulopathy.

50. Gastrointestinal Bleeding
oPatients with anticoagulants or with an
elevated PT and evidence of active bleeding
should receive sufficient FFP to correct the
PT.
oSerial platelet counts are used to determine
the need for platelet transfusions (i.e., less
than 50,000/mm3).

51. Gastrointestinal Bleeding
Blood Bank Blood
oshould be sent for “type and hold” or type and
crossmatch studies early in the patient’s care.
oImmediate transfusion needs in unstable
patients can be met with O-positive packed
red blood cells (O-negative packed red blood
cells in women of childbearing age whose Rh
status is unknown).

52. Gastrointestinal Bleeding
oType-specific blood is usually available within
10 to 15 minutes.
oGroup O blood and type-specific blood are
safe for patients and cause few transfusion
reactions.
oFully crossmatched blood may take 60
minutes to prepare.

53. Gastrointestinal Bleeding
Other Laboratory Tests
oElectrolytes usually normal
oUrea and creatinin

54. Gastrointestinal Bleeding
Patients with repeated vomiting,
may develop,
oHypokalemia
oHyponatremia
ometabolic alkalosis
correct with adequate hydration
and the resolution of vomiting.

55. Gastrointestinal Bleeding
oPatients with shock often have
metabolic acidosis from lactate
accumulation.
oHigh Urea as a result of
oabsorption of blood from the GI tract
ohypovolemia causing prerenal azotemia

56. Gastrointestinal Bleeding
ECG in all patients with a GI bleed who are
oolder than 50 years
opreexisting ischemic cardiac disease,
osignificant anemia
ochest pain
oshortness of breath
opersistent hypotension.
Asymptomatic myocardial ischemia may
develop in the setting of GI bleeding.

57. Gastrointestinal Bleeding
oPatients with GI bleeding and myocardial
ischemia should receive packed red blood
cells as soon as possible

58. Gastrointestinal Bleeding
Imaging
oNo need for plain abdominal radiography
unless aspiration or with signs and symptoms
of bowel perforation.
oair consistent with bowel perforation is a rare
finding with UGIB
oNeed immediate surgical consultation and
operative repair.

59. Gastrointestinal Bleeding
DIFFERENTIAL DIAGNOSIS
oSwallowing blood during epistaxis or from the
oral cavity may cause hematemesis or melena.
oRed vomitus may be due to food products
(e.g., Jell-O, tomato sauce, wine), and black
stool may be due to iron therapy or bismuth
(e.g., Pepto-Bismol).

60. Gastrointestinal Bleeding
MANAGEMENT
oQuick identification
oAggressive resuscitation
oPrompt consultation

61. Gastrointestinal Bleeding

After initial resuscitation of the patient,
oit is important to identify whether the
hemorrhage is proximal or distal to the ligament
of Treitz (i.e., UGIB or LGIB).
oIf the patient’s vomitus demonstrates blood,
then the diagnosis of UGIB is confirmed.

62. Gastrointestinal Bleeding
oIf a patient reports bloody or “coffee grounds”
emesis or if melenic stool is present, an
upper GI bleed is more likely.

63. Emergency management of patients with gastrointestinal bleeding. ED, emergency
department; IV, intravenous; LGIB, lower gastrointestinal bleeding; UGIB, upper
gastrointestinal bleeding.

64. Gastrointestinal Bleeding
Anoscopy/Proctosigmoidoscopy
oPatients with mild rectal bleeding who do not
have obviously bleeding hemorrhoids should
undergo anoscopy or proctosigmoidoscopy.
oIf bleeding internal hemorrhoids are
discovered, and the patient does not have
portal hypertension, the patient may be
discharged with appropriate treatment and
follow-up evaluation for hemorrhoids.

65. Gastrointestinal Bleeding
oIf hemorrhoids are not detected, it is
important to determine if the stool above the
rectum contains blood.
oabsence of blood above the rectum in a
patient who is actively bleeding indicates that
the source of bleeding is in the rectum.

66. Gastrointestinal Bleeding
oPresence of blood above the anoscope or
sigmoidoscope does not invariably indicate a
proximal source of bleeding, because
retrograde passage of blood into the more
proximal colon commonly occurs.
oSuch patients need further evaluation.

67. Gastrointestinal Bleeding
Endoscopy
oEndoscopy is the most accurate diagnostic
tool available for the evaluation of UGIB.
oIt identifies a lesion in 78% to 95% of patients
with UGIB if it is performed within 12 to 24
hours of the hemorrhage.

68. Gastrointestinal Bleeding
oEndoscopy-for upper GI bleeding.
oColonoscopy is an effective tool for diagnosis
and selected treatment of LGIB.

69. Gastrointestinal Bleeding
Angiography and Tagged Red Blood
oCell Scan Angiography can detect the location
of UGIB in two thirds of patients studied.
oSince the advent of endoscopy, however, the
use of angiography has decreased significantly,
and today angiography is used in only 1% of
patients with UGIB.

70. Gastrointestinal Bleeding
Nuclear isotope–tagged red blood cell scan
oIn some patients with more indolent or
elusive bleeding,
oUsually performed from the inpatient unit,
may identify the bleeding site.

71. Gastrointestinal Bleeding
Gastric Acid Secretion Inhibition
oAll patients with peptic ulcer disease
documented by endoscopy should receive
therapy with a proton-pump inhibitor (e.g.,
omeprazole).
oThere is no documented benefit to initiating
this therapy or administering H2 antihistamines
in the ED for patients with UGIB.

72. Gastrointestinal Bleeding
Octreotide (Somatostatin Analogues)
oIV infusion of octreotide at 25–50 μg/hour for
a minimum of 24 hours
oIn patients with documented esophageal
varices and acute upper GI bleeding
oshould receive in monitored bed.

73. Gastrointestinal Bleeding
oOctreotide is a useful addition to endoscopic
sclerotherapy and decreases rebleeding
occurrences.
oOctreotide may also reduce the incidence of
lower GI rebleeding secondary to
angiodysplasia.

74. Gastrointestinal Bleeding
Sengstaken-Blakemore Tube
oRarely used in tertiary care centre.
oShould not be used without endoscopic
documentation of the source of bleeding
because complications are common and
significant (14% major, 3% fatal).

75. Gastrointestinal Bleeding
oA trial of balloon tamponade should be
considered in an exsanguinating patient with
probable variceal bleeding in whom
endoscopy is not immediately available.
oConsultation with a surgeon or
gastroenterologist is advisable.

76. Gastrointestinal Bleeding
Surgery
oFor all hemodynamically unstable patients
with active bleeding who do not respond to
medical therapy.
oMortality rate for patients undergoing
emergency procedures for GI bleeding is
approximately 23%.

77. Gastrointestinal Bleeding
Emergency surgical consultation for :
oblood replacement exceeds 5 units
within the first 4 to 6 hours
or
o2 units of blood is needed every 4
hours

78. Gastrointestinal Bleeding
DISPOSITION
Risk Stratification
oRisk stratification involves combining
historical, clinical, and laboratory data to
determine the risk of death and rebleeding in
patients presenting to an ED with GI bleeding.

79. Gastrointestinal Bleeding
opatients present to the ED with a vague
complaint of vomiting blood or passing blood
from the rectum in whom detailed history and
examination allows a diagnosis of
hemorrhoid, or anal fissure, or there may be
little or no objective evidence of significant GI
bleeding…..Discharge pt with education
patients should be educated about the signs and
symptoms of significant GI bleeding and when to
return to the ED

80. Gastrointestinal Bleeding
oPatents should undergo specific follow-up
evaluation within 24 to 36 hours.
oThey should be instructed to avoid aspirin,
nonsteroidal anti-inflammatory drugs, and
alcohol.

82. THANK YOU