BENCE JONES PROTEIN.pptx

this is a biochemistry topic

1. BENCE JONES PROTEIN SANDHYA KUMARI

2. The Bence Jones Protein was described by the english physician Henry Bence Jones in 1847 and published in 1848. A Bence Jones Protein is a monoclonal globulin protein or immunoglobulin light chains found in the urine, with a molecular weight of 22-24 kDa . It is found in the blood or urine of about 40% of the patients with multiple myeloma . The protein is polypeptide consisting of a light chain type.

3. Causes of Bence Jones Proteins : Amyloidosis, benign monoclonal gammopathy , Cryoglobulinemia , Fanconi syndrome, hyperparathyroidism, multiple myeloma, osteomalacia , Waldenstromm’s macroglobulinemia . Test : Thermal methods ( waterbath ) : Proteins has unusual property of percipitating at (40˚C- 60˚C) & then dissolving when the urine is brought to boiling (100˚C) & reappears when the urine is cooled .

4. Clinical sign : The Bence Jones Protein urine test is used mainly to diagnose test is used mainly to diagnose and monitor multiple myeloma, a blood cancer .