Beri beri

IT IS CAUSED DUE TO VITAMIN B-1 DEFICIENCY.

1. BERI-BERI - BERI-BERI is a nutritional disorder caused due thiamin deficiency . -BY SUSHRITA SHRINIVAS ERABATHINI 1

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3. TYPES : It is of four major types : DRY BERI-BERI WET BERI-BERI CEREBRAL BERI-BERI INFANTILE BERI-BERI 3

4. DRY BERI-BERI 4

5. DEFINATION: It develops when diet chronically contains slightly less than the thiamin requirement SYMPTOMS: Poor appetite Peripheral neuropathy Fatigue Severe muscular weakness Deep muscle pain Pain on contact with the skin. 5

6. WET BERI-BERI 6

7. DEFINATION : It develops when the thiamin deficiency is more severe. SYMPTOMS : It is characterized primarily by: Edema of extremities Heart enlargement Cardiac insufficiency OTHER SYMPTOMS: Tachycardia Bradycardia Palpitation. 7

8. CEREBRAL BERI-BERI: 8

9. DEFINATION : It is also called as: WERNICKE-KORSAKOFF’S SYNDROME . Caused due to severe deficiency of Thiamin . PECULARITY: Seen most commonly in alcoholics compared to the general population; the chronic heavy alcohol consumption interferes with the intestinal absorption if thiamin . 9

10. Also can get worsen by a mutation in the gene for transketolase that results in reduced affinity of transketolase for TPP. SYMPTOMS: G astrointestinal symptoms: Anorexia Nausea Ataxia 10

11. Neurological symptoms: Loss of memory Depression Mental confusion Ataxia Ophthalmological symptoms: Nystagmus Double vision Skeletal symptoms: Peripheral paralysis Muscular weakness 11

12. INFANTILE BERI-BERI 12

13. DEFINATION: Observed in breastfed infants born to mother suffering from thiamin deficiency. The breast milk of these mothers is deficient in thiamin . SYMPTOMS: Cardiac dilation(enlargement of heart) Tachycardia Convulsions Edema Vomiting Abdominal colic In acute condition, infant may die due to cardiac failure. 13