Bioelectronics and biosensors

1. Bioelectronics and biosensors By K.Gautham Reddy 2011A8PS364G

2. Introduction Bioelectronics: Integration of molecules with electronic elements biosensor   - analytical device, used for the detection of an analyte, that combines a biological component with a physicochemical detector.

3. Applications Prosthetic Devices Artificial organs Biofuel cells B rain computers Blood glucose biosensor with insulin pump

4. Nanotechnology in bioelectronics Offer new opportunities for investigating complicated biological process The unique optical, magnetic, and mechanical properties of functional nanomaterials

5. Silicon nanomaterials Why silicon? Abundance Biodegradable Biocompatable Less toxic Exists as trace element in humans

6. Silicon Nanoparticles Fluorescent Probes for Bioimaging Applications Best noninvasive method Fluorescent probes are of essential for labeling the targeted biomolecules Fluorescent SiNPs are regarded as an ideal biological probe because low-toxicity of silicon . U niquely suitable for long-term cell imaging(small size ≈5nm)

7. Hydrophobic SiNPs are first produced from large-size silicon materials Surface modification with hydrophilic ligands SiNPs are much more photostable than organic dyes

8. SiliconNanowires for Biosensing Applications Biosensing useful in food safety,disease diagnosis and environmental protection. Silicon nanowires ( SiNWs ) have been used because of their biocompatibility , surface tailorability , fast response, and good reproducibility. SiNW -based FET assisted by integration with live mammalian neurons and individual axons, which used for accessing valuable information on neurons

9. SiNWs coated with cell capture agents for construction of a new circulating tumor cell (CTC)-capture platform, yielding high CTC-capture efficiency AgNPs@SiNWs is used for detection of pH changes with high sensitivity in an aqueous environment.

10. SiNW Nanoagents for Cancer Therapy Metal nanoparticle decorated SiNWs exhibit unique electronic and optical properties . SiNWs has strong absorbance in the NIR range AuNPs acting as heat producer featured high conversion efficiency of NIR light to heat .

11. AuNP_SiNW complex could rapidly generate high heat under NIR irradiation SiNW -based hyperthermia was universal for malignant tumor cells as it killed all kinds of cancer cells in 3min NIR irradiation Power density of AuNPs@SiNWs used to irradiate cells is smaller than other nanomaterial.