Biosynthesis of heme (flowchart)

This Video shows you the various important steps Biosynthesis of Heme flowchart

1. Biosynthesis of Heme[Flowchart]

2. Biosynthesis of Heme
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Succinyl CoA + Glycine
δ Aminolevulinic acid (ALA)
Prophobilinogen (PBG)
Hydroxymethylbilane (HMB)
ALA synthase [
Rate Limiting Step
]
ALA dehydrogenase [Zn
2+
]
Uroporphyrinogen- III (UPG III)
Coproporpyrinogen- III
UPG decarboxylase
Uroporphyrinogen- synthase
Uroporphyrinogen- III synthase
CYTOPLASM
MITOCHONDRIA
Heme
Corporphyrinogen
Oxidase
(in Mitochondria)
Protoporphyrinogen- IX
Ferrochelatase
(heme synthase)
Fe
+2
All Cells Except RBC [Lacks Mitochondria]
Mostly in Liver and Bone Marrow
(-) Lead Poisoning
↑ 4 CO
2

3. Brain Teaser
The Decarboxylation of Uroporhyrinogen takes place in Cytoplasm ?
True / False