The four principal types of bones are long, short, flat and irregular. Bones that are longer than they are wide are called long bones. They consist of a long shaft with two bulky ends or extremities.
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Bones & Classification 16-12-2022 1
Objectives Skeleton Bone Microscopic structure Characteristics Classifications of bone Gross structure Epiphyses Blood supply MCQ Clinical Vignettes References 16-12-2022 2
Skeleton Form a rigid frame work of body Composed of :- Bones Cartilages 16-12-2022 3 Made up of specialised supporting connective tissue called Sclerous (skeletal) tissue
Appendicular skeleton Bilaterally symmetrical Comprises bone Upper limb and Lower limb with bony girdles 16-12-2022 6
Bone Os (Latin) Osteon ( Greek) Hard structure , form rigid framework of body 16-12-2022 7
Structurally Highly vascular mineral connective tissue Specialized form of connective tissue Distinguish feature from other connective tissues is Mineralization of its matrix Mineral is calcium phosphate hydroxyapatite crystals [Ca10(PO4)6(OH)2]. 16-12-2022 8
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Microscopic Structure Cells Ground substance + fibre , form the extracellular substance or matrix 16-12-2022 10
Bone Matrix Organic (no calcified ) Type 1 collagen Non mineralized ground substance Chondroitin sulfate Keratin sulfate Provide resilience Inorganic (calcified) Contain crystalline mineral salt (calcium , phosphorus) Osteoid undergo mineralization process Provide hardness and rigidity 16-12-2022 11
Ground substance or Matrix Mainly type I collagen and types III,XI,XIII collagens in trace amount Other matrix, (Noncollagenous)proteins that constitute ground substance of bone. Proteoglycan macromolecules Multiadhesive glycoprotein's Bone-specific, vitamin K–dependent proteins 16-12-2022 12 Both collagen and ground substance become mineralized to form bone tissue
Cells Osteoproginator cells Osteoblast Osteocytes Osteoclast 16-12-2022 13 Bone matrix contains lacunae connected by a network of canaliculi
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Characteristics Living tissue Highly vascular Serves as a storage site for calcium and phosphate Supply by nerve and blood vessel Show pattern of growth Subjected to disease & heal after fracture Regenerative power 16-12-2022 16
Classification of bone According to shape According to structure According to development 16-12-2022 17
Acc to shape of bone 16-12-2022 18
Long bone Typical long bones humerus , radius, ulna, femur, tibia, fibula; Miniature long bones have only one epiphysis e.g. metacarpals, metatarsals and phalanges; 16-12-2022 19
2. Short bones: Shape is usually cuboid , cuneiform, Trapezoid or scaphoid . Examples: tarsal and carpal bones 16-12-2022 20
3. Flat bones Shallow plates Form boundaries of b ody cavities. Examples: Vault of skull, ribs, sternum & scapula 16-12-2022 21
4. Sesamoid bone Bony nodules found embedded in tendons or joint capsules. No periosteum and ossify after birth Functions are: (a) To resist pressure & friction (c) To alter direction of pull of muscle (d) To maintain local circulation. 16-12-2022 22
6. Pneumatic bone Irregular bones contain large air spaces lined by epithelium examples: maxilla, sphenoid, ethmoid . Function:- Make skull light in weight, Help in resonance of voice, Act as air conditioning chambers for inspired air 16-12-2022 24
7. Accessory bone (supernumerary bone) Not always present . Developed from extra-centres of ossification. Examples: Sutural bones, os trigonum (lateral tubercle of talus), os vesalianum ( tuberosity of 5 th metatarsal) 16-12-2022 25
Structural classification Macroscopically, Compact bone Cancellous bone 16-12-2022 26
Compact bone consist of Lamella of collagenous sheet Haversian system or osteon 16-12-2022 27
Cancellous bone/ spongy bone Meshwork of bony spicules . Do not form haversian system Architecture of cancellous bone is depend upon trajectory theory (Wolf’s law) Pressure lamellae Tension lamellae 16-12-2022 28
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Microscopically Classification is based on arrangement of different component in matrix are arranged Woven bone – Collagen fasiscle and bony crystal arranged in mesh network, like woven fabric e.g , callus bone , young fetal bone Lamellar bone- Mineralized matrix arranged in layer of thin sheet e.g. All adult bone 16-12-2022 31
Woven bone lamellar bone Lamellar appearance - arrangement of collagen fibres Woven bone is weak- repair of fracture
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Gross structure 16-12-2022 34
Epiphyses Type of epiphyses 16-12-2022 35
Blood Supply Supplied by following 4 set of Arteries Nutrient arteries Metaphyseal arteries Epiphyseal Periosteal arteries 16-12-2022 36
Developmental classification Membranous bones Cartilaginous bones Membrano - Cartilaginous bones 16-12-2022 37 Types of bones Examples Membranous Bones of cranial vault Facial bones Cartilaginous Bone of limbs Bones of base of skull Bones of vertebral column Bones of thoracic cage Membrano-cartilagnous Mandible Clavicle
Intramembranous Ossification Develop from mesenchymal model 16-12-2022 38
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Intra-cartilaginous Ossification Develop from cartilaginous ossification 16-12-2022 40
Intra-cartilaginous Ossification 16-12-2022 41
Clinical Paget’s disease 16-12-2022 42
MCQ Mainly all bone in the body is made up of both compact and spongy bone, except Clavicle Inferior nasal choncha Patella fabella 16-12-2022 43 Inferior nasal choncha
Name muscle in which fabella bone usually develop? Lateral head of Gastrocnemius Long head of biceps femoris Popliteus Adductor longus 16-12-2022 44 Lateral head of Gastrocnemius
Clinical Vignettes A 7 year old boy come to an orthopaedics clinic, having a fever, swelling and redness over knee, complain of fatigue and having a history trauma few weeks ago. An X-ray reveal a lesion over tibia, Doctor diagnose a osteomyelitic lesion. Q Name the part of growing long bone commonly effected by osteomyelitis? 16-12-2022 45 Ans Metaphysis
A 12 year old child born with a condition called Cleidocranial dysostosis , as shown in image. Q what type of development is shown by clavicle? a) Cartilaginous development b) Membranous development c) Membrano – cartilaginous 16-12-2022 46 Membranous development
References Vishram Singh general anatomy e.2014 Histology_ A Text and Atlas_ With Correlated Cell and Molecular Biology, 6th Edition Keith L. Moore Clinically Oriented Anatomy, Sixth Edition . 16-12-2022 47