BRAIN TARGETED DRUG DELIVERY

In this include
brain targeted drug delivery
we can see that in a brain there are a barrier it is known as blood brain barrier. so how we can cross those barrier is a important discussion for us to target the drug in brain.

1. DEPARTMENT OF PHARMACY GURU GHASIDAS VISHWAVIDYALAYA PRESENTATION ON ROLE OF NANO-PARTICLE IN BRAIN TARGETED DRUG DELIVERY SUBMITTED BY PRABHAT DEWANGAN M. PHARM 1 ST (PHARMACEUTICS)

2. CONTENT: Introduction Role of nanoparticles in brain specific delivery Mechanism for transport Advantage Limitations

3. INTRODUCTION: The treatment of brain disease ( Parkinson’s, Epilepsy, Meningitis ) is a complex and limited due to the presence of blood brain barrier. The BBB protecting brain from harmful substances but it is metabolic barrier and transport regulator of nutrient and because of this reason brain delivery system mostly based on nanotechnology. Nanoparticles drug delivery system is one of the advanced technology that can be utilized to deliver drug molecules directly into the brain and proved to be very effective against several CNS disorders. Nanoparticle mainly reduce side effect increase drug concentration in the

4. site of action therefore increase therapeutic effect. ROLE OF NANOPARTICLE IN BRAIN SPECIFIC DELIVERY: The nanoparticles as a targeting drug delivery system may include, The particle size ranging from 1 to 100 nm, having ability to target particular organ or tissue. Having property of hydrophobicity and lipophilicity are made up of biocompatible and biodegradable polymers. There are different types of nanoparticles, Nano-spheres 2. Nano-capsules

5. MECHANISM FOR TRANSPORT: The mechanism for transport of lipoprotein to be endocytosis via the low density lipoprotein. Receptor of the endothelial cells after adsorption of lipoproteins from blood plasma to the nanoparticles. It is suggested that the recognition and interaction with lipoprotein receptors on brain capillary endothelial cells is responsible for the brain uptake of the drug.

6. ADVANTAGE OF USING NANOPARTICLES FOR CNS TARGETED DRUG DELIVERY SYSTEM: Nanoparticles protect drugs against chemical and enzymatic degradation. Due to their small size nanoparticles penetrate into even small capillaries and are taken up within cells, allowing an efficient drug accumulation at the targeted sites in the body degradation. The use of biodegradable materials for nanoparticles preparation, allows sustained drug release at the targeted site after injection over a period of days or even weeks. They are also able to reduce side effects of some active drugs.

7. LIMITATION FOR USING NANOPARTICLES FOR CNS TARGETED DRUG DELIVERY: Their small size and large surface area can lead to particle- particle aggregation, making physical handling of nanoparticles difficult in liquid and dry forms. In addition, small particles size and large surface area readily result in limited drug loading and burst release.

8. Thankyou REFERENCE: A. Misra, S. Ganesh, A. Shahiwala , and S.P. Shah, "Drug delivery to the central nervous system: a review", J Pharm Pharm Sci, Vol. 6, pp. 252-73,2003. W. M. Pardridge , "Blood-brain barrier drug targeting: the future of brain drug development", Molecular interventions, Vol. 3, pp. 90,2003. R. Singh and J.W. Lillard, "Nanoparticle-based targeted drug delivery", Experimental and molecular pathology, Vol. 86, pp. 215- 223,2009.