Capsule

some important information about capsule: By this presentation you can learn about different types of capsule, their formulation , advantage, disadvantage etc.

1. WELCOME t0 0ur presentation

2. Presentation On: capsule Presented by: Md Mohabbot Hossen Batch : 19th Department of Pharmacy Dhaka International University

3. PRESENTATION OUTLINE Introduction. Advantages of capsule. Disadvantages of capsule. Gelatin. Five basic properties of gelatin. Types of gelatin. Manufacture of gelatin. General properties of gelatin. Types of capsule. Hard gelatin capsule. Capsule size. Manufacture. Soft gelatin capsule. Composition of SGC. Shapes and sizes of SGC. Advantages of SGC . Disadvantages of SGC . Manufacture of SGC . Rotary die machine. Difference between SGC and HGC.

4. INTRODUCTION

5. ADVANTAGES OF CAPSULE

6. DISADVANTAGES OF CAPSULE 1 2 4 3

7. GELATIN Gelatin is a protein substance derived from collagen. It is a natural protein present in the tendons, ligaments and tissues of mammals. It is produced by boiling the connective tissues, bones and skins of animals, usually cows and pigs. It is the major component of capsule.

8. FIVE BASIC PROPERTIES OF GELATIN Non toxic. Soluble in biological fluid at body temperature. Good film forming material. Solution of high concentration, 40% w/v are at 50 ◦ c . A solution in water changes from a sol to a gel at temperatures only a few degrees above ambient.

9. TYPES OF GELATIN TYPE A : Derived from acid treated precursor that exhibits an isoelectric point at pH-9.It is manufactured mainly from pork skin . TYPE B : Derived from alkali treated precursor that exhibits an isoelectric point at pH-4.7.It is manufactured mainly from a nimal bones .

10. MANUFACTURE OF GELATIN

11. GENERAL PROPERTIES OF GELATIN Bloom value: Gelling power: Viscosity: Foamability : Gelatin generally falls between 50 and 300 bloom strength. The gelling power varies depending on the grade of gelatin. The higher the bloom , the greater the viscosity. Pig skin grades tend to have better foaming properties.

12. GENERAL PROPERTIES (CONTINUED) 5. Melting point: 6. Color and odor: 7. pH: Lower melting point gelatin dissolve faster in the mouth . Lower bloom grade tend to have lower melting point. The gelatin should be clear and without odor. pH is a measured using a pH meter on a 1% solution are typically for gelatin solutions falls between pH 4.5 and 6.5.

13. TYPES OF CAPSULE Capsules are generally 2 types: 1 Hard gelatin capsule 2 Soft gelatin capsule

14. HARD GELATIN CAPSULE The hard gelatin capsule consist of a base or body and a shorter cap. It contains: 12 -16% moisture Dry solids Powders Granules Tablets Colorant Preservatives 1 2 3 4 5 6 7

15. CAPSULE SIZE For human use generally 8 sizes of capsule available: size volume(ml) 000 1.37 00 0.95 0.68 1 0.5 2 0.37 3 0.3 4 0.21 5 0.13

16. MANUFACTURE OF EMPTY GELATIN CAPSULE Spinning Dipping Drying Stripping Cutting Joining

17. SOFT GELATIN CAPSULE

18. COMPOSITION OF SGC

19. SHAPES AND SIZES OF SOFT GELATIN CAPSULE OBLONG ROUND OVAL SUPPOSITORIES SPECIAL SHAPES

20. ADVANTAGES OF SOFT GELATIN CAPSULE 1 Easy to administer 2 Easy to manufacture 5 Small to large sizes possible 3 Elegance 4 Portability 6 Odor and taste masking possible

21. DISADVANTAGES OF SOFT GELATIN CAPSULE 1 High cost 4 Chance of interaction 2 preparation Fill material 3 5 Some liquid can not be used

22. MANUFACTURE OF SOFT GELATIN CAPSULE 1 Rotary die process Plate process 2

23. ROTARY DIE MACHINE

24. DIFFERENCE BETWEEN SGC AND HGC Criterion Shell Content Manufacture Sizes and shapes formulation technology Fill accuracy Soft gelatin capsule Hard gelatin capsule Plasticized Not plasticized Usually in liquid form Usually in dry solids Formed and filled in one operation Shells made in one operation and filled in a separate process Many Limited Liquids Solids More Less

25. Thank You