CARDIAC CYCLE-I
DR. KANIMOZHI SADASIVAM, MD
PROFESSOR
DEPT OF PHYSIOLOGY
OBJECTIVES
Definition & phases of cardiac
cycle
Heart sounds
The mechanical, electrical &
other events occurring during
the cardiac cycle
CARDIAC CYCLE
The sequence of cyclical events
that take place during one heart
beat (one systole and one
diastole) to the beginning of the
next
EVENTS DURING THE
CARDIAC CYCLE
Mechanical – volume & pressure
changes
Electrical - ECG
Chemical
Thermal
Changes in position of heart & apex
beat
Movement of the valves
Heart sounds
CARDIAC CYCLE
Heart rate : 72/min
Hence duration for one cycle is: 60/72 = 0.8 seconds
Atrial cycle
Atrial systole -0.1 sec
Atrial diastole-0.7 sec
CARDIAC CYCLE
IF HR ↑ - 150 / MIN
CARDIAC CYCLE – 0.4 Sec
SYSTOLE 0.25 Sec
DIASTOLE – 0.15 Sec
Hence little time for ventricular
filling.
CARDIAC CYCLE
RA contracts before LA
LV contracts before RV
S D-0.7
D S-0.3 D-0.4
ATRIAL EVENTS
VENTRICULAR EVENTS
Whole heart is Quiescent
ATRIAL SYSTOLE
0.10 Sec
Coincides with last rapid phase of
ventricular diastole
Coincides with ‘a ’ wave of JVP
Contraction of atria-Fourth Heart
sound
AV valves opened
Increases the ventricular filling by
30%
ATRIAL DIASTOLE
Duration: 0.7sec
Coincides with VS & most of the VD
Beginning of AD- 0.3sec – AV valves closed
Pressure decreases in atria and increase in
ventricle.
Late of AD- 0.4sec – AV valves opened
Pressure falls in the ventricles
Contribute to 80% ventricular filling
ISOVOLUMETRIC
CONTRACTION
0.05 Sec
Coincides with c wave in JVP
Semilunar valve : Closed
AV valves closed – First Heart sound
Closed chamber – Contracts
No change in the volume
Intraventricular pressure ↑
EJECTION PHASE
↑ Intraventricular pressure
> 80mm Hg - Diastolic pressure
of Aorta (Or) > 10mmHg-
Diastolic pressure of Pulmonary
arteries
Semilunar valves forced to open
Blood flows into arteries from
ventricle
EJECTION PHASE
0.25 Seconds
RAPID EJECTION PHASE – 0.10 SEC
Due to High Pressure gradient - Blood is ejected into
Aorta / Pulmonary artery.
SLOW EJECTION PHASE – 0.15 SEC
Due to decreased Pressure gradient
STROKE VOLUME = 80 ml (Blood ejected out by each
ventricle during each systole)
END DIASTOLIC VOLUME= 130ml
END SYSTOLIC VOLUME = 50ml
EDV – SV = ESV [130 – 80 = 50]
PROTODIASTOLIC
PHASE
0.04 Sec
Ventricle relaxes
Intraventricular pressure falls
Blood flows back from aorta /
pulmonary artery into ventricle
Semilunar valve closes - Second
heart sound
Dicrotic notch seen in the aortic
pressure
ISOVOLUMETRIC
RELAXATION
0.06 Sec
SLV and AV valves closed
Ventricle relaxes as closed
chamber
No volume change
Intraventricular pressure ↓
At the end AV valve open- v wave
RAPID PASSIVE FILLING PHASE
0.10 sec
↓Intraventricular pressure
< intra atrial pressure
Hence AV valves open
Blood flows from atria to
ventricle (70%)
Third heart sound
REDUCED FILLING/DIASTASIS
0.20 Sec
in intraventricular pressure
Blood flows from atria to
ventricle at slow rate (10%)
LAST RAPID FILLING PHASE
0.10 Sec
Coincides with atrial systole
20% of ventricular filling
HEART SOUNDS
Due to dynamics of blood flow
Valvular,
Vascular
Muscular vibrations
2 audible heart sounds
lubb, dupp
4 recordable heart sounds
AUSCULTATION AREAS
2
nd
ICS
Right sternal border
5
th
ICS
Left sternal border
2
nd
ICS
Left sternal border
5
th
ICS
Apex beat
AUSCULTATION AREAS
AORTIC
PULMONARY
TRICUSPID
MITRAL
FIRST HEART SOUND-S1
Character – Low pitch,
Booming, longer
Duration : 0.1 - 0.17 sec.
Frequency : 24 – 45 / sec
Best heard in :
Mitral & Tricuspid area
Closure of AV valves – LUBB
Vibrations of Chordae
tendinae
Vascular – Turbulence of
blood flow
Muscular – vibrations in
ventricular muscle as it
starts to contract
Coincides with :
Isometric contraction
phase
Peak of R wave of ECG
Phlebogram – Onset of
C wave
Has 2 components
Mitral – M
1 & Tricuspid –
T
1
Mitral precedes tricuspid
due to earlier closure of
Mitral valves
SECOND HEART SOUND-S
2
Character : High pitched
Duration : Shorter , 0.10 -
0.14 sec
Frequency : 50 Hz / sec
Best heard in : Aortic and
Pulmonary area
Closure of Semi Lunar Valves
– DUPP
Coincides with :
Onset of ventricular
diastole(Protodiastole)
Preceded/coincides or
follows T wave
Phlebogram – Ascending
limb of v wave
2 components
•Aortic (A2) & Pulmonary (P2)
•Normally P2 softer than A2
S
1 and S
2
S
1 - beginning of Ventricular
systole
S
2 – end of ventricular systole
Interval between S
1
& S
2
–
Duration of ventricular systole
Interval between S
2 & S
1 –
Duration of ventricular diastole
THIRD HEART SOUND-S3
Low intensity
Duration : 0.07 - 0.1 sec
Low frequency : 20Hz
Low pitched. Can be recorded
by Stethograph
Due to Rapid ventricular
filling
Vibrations of ventricular
wall
Frequently heard in
children
Thin walled chest
Patient with
Ventricular failure
If heard in adult –
cardiac abnormality
(eg. Mitral
regurgitation)
FOURTH HEART SOUND-S4
Not heard in normal
subjects
Only recorded
Just before first
heart sound
Freq < 20 Hz
Atrial systole causes
vibrations of atrial
wall, AV valves and
ventricular walls
Heard in abnormal
conditions –
hypertrophy of
atrium
Absent in atrial
fibrillation
Recorded by stethograph
PHONOCARDIOGRAM
Graphic recording of heart
sounds
Duration, amplitude and
frequency of vibrations
Clinical Significance
Useful for detecting
abnormalities in heart sound
Variations in heart sounds
Loudness, length, interval
between sounds
Splitting of sounds
Additional sounds
Murmurs