Catabolism of Heme | Jaundice | Hyperbilirubinemia

This PPT contain topics on Catabolism of heme; hyperbilirubinemia and jaundice
Books referred: https://www.amazon.in/Biochemistry-2019-Satyanarayana-Satyanarayana-Author/dp/B07WGHCTKZ/ref=sr_1_1?dchild=1&qid=1592209115&refinements=p_27%3AU+Satyanarayana&s=books&sr=1-1

2. Catabolism of heme
•Bilirubinis a bile pigment, and is the excretory
end product of hemedegradation.

3. Catabolism of heme
•HemoglobinHeme
•HemeBiliverdinby “Hemeoxygenase”
•BiliverdinBilirubinby “Biliverdinreductase”
•BilirubinBilirubindiglucuronideby “Bilirubin
glucuronyltransferase”glucuronyltransferase”
•BilirubindiglucuronideUrobilinogenby “Microbial
enzymes”
•UrobilinogenUrobilin(To urine)
•UrobilinogenStercobilin(To feces)

4. BLOOD CELLS
Hemoglobin
Heme
INTESTINE AND KIDNEY
Urobilinogen
Urobilin
Excreted in Urine
Stercobilin
Excreted in Feces
Biliverdin
Bilirubin
LIVER
Bilirubindiglucuronide
Bilirubin

5. JAUNDICE
•Jaundice:Clinical condition characterized by
yellow colourof the white of the eyes (sclerae)
and skin. Caused by the deposition of bilirubin
due to its elevated levels in the serum, usually due to its elevated levels in the serum, usually
beyond 2 mg/dl (normal < 1 mg/dl).
•Hyperbilirubinemia: The increased concentration
of serum bilirubin.

6. •Bilirubinconcentration range:
–Normal serum total bilirubinconcentration:0.2 to
1.0 mg/dl. 1.0 mg/dl.
–Unconjugated: 0.2-0.6 mg/dl.
–Conjugated: 0.2 to 0.4 mg/dl.

7. 3 types of jaundice and major changes
Hemolytic jaundice:Elevated serum unconjugated
bilirubin, and increased urinary excretion of
urobilinogen.
Obstructive jaundice:Elevated serum conjugated
bilirubinand increased activities of alkaline bilirubinand increased activities of alkaline
phosphatase (ALP), alanine transaminase (ALT) and
aspartatetransaminase(AST).
Hepatic jaundice:Elevated serum unconjugatedand
conjugated bilirubin, and increased activities of ALT
and AST.