Cepodem XP 325 Tablet Side-effects Below are Side-effects of Cepodem XP 325 Tablet : Side effects of Cefpodoxime Proxetil For many, the drug is boon while it can become a bane for others. This is because it can cause certain side effects on the body of some patients. Some of the commonly reported side effects of the drug include; diarrhea, feeling restless or hyperactive,constipation,tired feeling,flushing (warmth or redness under your skin), nervousness,dizziness,white patches or sores inside your mouth or on your lips,stiff or tight muscles,anxiety,spinning sensation,unusual or unpleasant taste in your mouth,bloating,numbness or tingly feeling,gas,diaper rash in kids, headache,stomach pain,nausea , itching . Side effects of Cefpodoxime Proxetil Hypersensitivity reactions, nausea, vomiting, eosinophilia, severe diarrhea, hepatic cholestasis, fever, maculopapular rash, urticaria , increase in serum transaminase.