Chelation theraphy presentation download

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1. Chelation therapy

2. Chelation therapy Chelation therapy is a method for removing heavy metals from blood such as mercury or lead  Chelating agent Chelating agents are chemical compounds that react with metal ions to form a stable, water-soluble complex. They are also known as chelators

3. Chelation therapy Chelating agent is an polydentate ligand

4. chelation therapy Metal complexes BAL [British anti lewisite] EDTA [ethylene diamine tetra acetic acid DMPS [di mercapto 1-propane sulphonicacid] DMSA [DI mercapto succinic acid] DPA & NAPA [D –pencillamine, N acetyl pencilamine]

5. BAL

6. BRITISH ANTI LEWISITE

7. EDTA

8. EDTA EDTA and DCTA form strong complex Na salt of EDTA induce Ca deficiency of the bone [hypocalcemia] EDTA forms chelate with Pb, Na2 Pb EDTA Water soluble, non toxic, non ionised, non metabolished and is excreted through urine EDTA is a superior chelating drug compared to BAL It is used for the treatment of the toxicity of As & Hg

9. DMPS 2,3 di mercapto 1- propane sulphonic acid

10. DMPS

11. DMSA It can be used for detoxification of soft metals as Pb, Hg and As

12. DPA & NAPA Both drugs has SH group NAPA is better then DPA These are hydrolysis product of pencilline

13. Thank you