Chemical Mediators of Acute Inflammation

An overview of the various chemical mediators involved in acute inflammation in the human body

1. Chemical Mediators of Acute Inflammation Prepared by: Rawa Muhsin

2. Types of Mediators 2

3. Types of Mediators 3

4. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 4

5. Histamine 5

6. Histamine 6

7. Serotonin 7

8. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 8

9. Cytokines 9

10. IL-1 and TNF 10

11. IL-1 and TNF 11

12. Chemokines 12

13. Chemokines 13

14. Chemokines 14

15. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 15

16. Eicosanoids 16

17. Eicosanoids 17

18. Eicosanoids 18

19. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 19

20. Reactive Oxygen Species 20

21. Reactive Oxygen Species 21

22. Reactive Oxygen Species 22

23. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 23

24. Nitric Oxide 24

25. Nitric Oxide 25

26. Nitric Oxide 26

27. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 27

28. Leukocytic Lysosomal Enzymes 28

29. Leukocytic Lysosomal Enzymes 29

30. Leukocytic Lysosomal Enzymes 30

31. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 31

32. Neuropeptides and PAF 32

33. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 33

34. Complement System 34

35. Complement System 35

36. Complement System 36

37. Complement System 37

38. The Mediators Cell-Derived Mediators Vasoactive Amines: Histamine and Serotonin Cytokines: IL-1, TNF, and Chemokines Eicosanoids Reactive Oxygen Species Nitric Oxide Leukocytic Lysosomal Enzymes Neuropeptides and PAF Plasma Protein-Derived Mediators Complement System Coagulation and Kinin Systems 38

39. Coagulation and Kinin Systems 39

40. Types of Mediators 40

41. Thank you for listening. 41