cholesterol synthesis

cholesterol synthesis

1. By ArnavKaushal

2. Introduction
žCholesterol is constituent of all cell
membrane. Necessary for synthesis of
steroid hormones, bile salts and Vitamin
D. Normal level <200mg/dl.
Abnormality of cholesterol metabolism
may lead to cardiovascular disease and
heart attacks.

3. Functions of Cholesterol
žCholesterol packs phospholipids from both
the sides of cell membrane and therefore
maintains stability and stiffness of cell.
žCholesterol is responsible for proper
synthesis of neurotransmitters.
žCholesterol plays an important role in
synthesis of Vitamin D3 and hormones
including aldosterone, cortisol, estrogen,
cortisone, progesterone.
žCholesterol is a precursor to other vital
molecules that are important for functioning
of the body

4. Structure of cholesterol
žIts molecular formula is C27H46O.
Cholesterol contains steroid rings with a
hydroxyl group, two methyl groups and
a hydrogen tail.

6. Synthesis
Biosynthesis of cholestrolis considered a Complex
method. The carbon atoms in cholestrolstructure
provided by single precursor ACETYL CoA.
Synthesis of cholestolcan be studied conveniently in
5 stages~
žFormation of HMG CoA
žSynthesis of mevalonate
žGeneration of isoprenoidunits
žSynthesis of squalene
žFormation of cholesrol

9. Fate of Cholesterol
žCholesterol can be exported and
transported to other tissues via LDL
žConverted to bile acids and secreted
into the intestines.
žUsed up in formation of cell membrane.
žUsed in formation of VIT.D and steroid
hormones.

10. QUESTION
Q)Ring system of cholesterol is
known as-
A) Cholanthrenering
B) Cyclopentanophenanthrene
C) Napthoquinone
D) Corrinring

11. key enzyme in pathway of
cholesterol biosynthesis is?

12. THANKS GENIUSES