Colonitis by goxkxyxyodofyodfoydyoj.pptx

.

1. Clinical pharmacology of Colonitis By Deepak Kumar GM20-098

2. Inflammatory Bowel Disease ▶ Inflammatory bowel disease (IBD) is an umbrella term used to describe disorders that involve chronic inflammation of the digestive tract. ▶ Types of IBD include: ▶ Ulcerative colitis ▶ Crohn's disease

3. Pharmacological Management ▶ 5- Aminosalicylic Acid (5- ASA, Mesalamine) ▶ Corticosteroids ▶ Immunomodulating Drugs ▶ Biologic Agents ▶ Antibiotics ▶ Probiotics

4. 5- Aminosalicylic Acid (Mesalamine)

5. 5- Aminosalicylic Acid ▶ Mesalamine is an anti- inflammatory agent ▶ It is an Aminosalicylate ▶ Generic Name- SULPHASALAZINE ▶ Trade Names - Azulfidine, PMS Sulfasalazine , PMS Sulfasalazine

6. Contd… ▶ Classifications: Gastrointestinal agent; mucous membrane agent; anti- inflammatory; sulphonamide ▶ Availability- 500 mg tablets; 500 mg sustained release tablets

7. Mechanism of Action ▶ Locally acting sulfonamide. ▶ Believed to be converted by intestinal microflora to sulfapyridine (provides antibacterial action) ▶ Also has an anti- inflammatory effect. ▶ It also helps in inhibition of prostaglandins known to cause diarrhea and affect mucosal transport, and interference with absorption of fluids and electrolytes from colon.

8. Indications ▶ Ulcerative colitis ▶ Regional enteritis ▶ Rheumatoid arthritis.

9. Contraindications ▶ Sensitivity to sulfasalazine ▶ Agranulocytosis ▶ Children <2 y ▶ Intestinal and urinary tract obstruction ▶ porphyria

10. Route & Dosage ▶ Ulcerative Colitis Adult: PO 1–2 g/d in 4 divided doses, may increase up to 8 g/d if needed Child: PO 40–50 mg/kg/d in 4 divided doses (max: 75 mg/kg/d)

11. Pharmacokinetics ▶ Absorption: Readily absorbed from GI tract. ▶ Distribution: Crosses placenta. ▶ Metabolism: Extensively metabolized in liver to active metabolite mercaptopurine. ▶ Elimination: Eliminated in urine. ▶ Half- Life: 3 h