Conscious Design

Institutions-Linked-In and Multiply Socially Conscious Minds and Assure Quality of Goods & Services.

1. …Is it Essential ? On Quality (of Life) by Design.

2. The Question Sounds like: Is It Essential to Eat Good Fresh Balanced Indigenous Diet? Or Can I keep the Option of Eating Fresh Garbage?

3. ‘Sales' depend on the Product QUALITY * Intended PURPOSE * Product PERFORMANCE These three should be built-in during PRODUCT DESIGN and Manufacturing. Thus every one involved in the ‘product DESIGN and manufacturing’ must have an idea of the sales part of it. “High grade-High QUALITY-Low price is given top priority” But in the competitive world Low grade-High QUALITY is preferred over High grade-Low QUALITY. Thus at the end of the day it is about the High QUALITY product suitable for intended PURPOSE” with promised “PERFORMANCE. (CURRICULUM DESIGN, Teaching &Training, and Duty/Job/Employment)

4. Material Path Spiritual Path Synchronized Path Confused State Synchronized Path will help Defeat: Excessive Joy Jealousy, Fear, Anger, Sadness, Sorrow Greed, Corruption

5. Is It About MINDSET ? Excessive Joy...may be a sing of….Circulation & LV malfunction Jealousy………..may be a sign of….Too many Toxins in Blood Fear………….....may be a sign of…..Kidney malfunction Anger……….....may be a sign of…..Liver malfunction Sadness……….may be a sign of..…Lungs, Intestine malfunction Sorrow………..may be a sign of….Spleen, Digestive malfunction Greed…….......may be a sign of........Metabolic disturbance Corruption…..may be a sign of………Total System Failure Learning Period Earning Period …that depends on many factors

6. "Evil is Powerless, if the Good are Unafraid“ ...Ronald Reagan. I believe, from what I have understood so far, this is the essence of all the ancient world wisdom traditions. 'Goodness' is the healthy state of mind and that in turn will never intentionally commits any wrong doing and that is why unafraid (i.e., defeats fear and anger because there is no self interest (desire), there is no 'I' or 'Mine' thing in the duty therefore absence of Ego). The only thing that is there is 'We‘, which is the collective 'I' (i.e., team work), and the only duty that is there is 'serving the society'. God bless all with good health and longevity. … D r. K. V. Sarma Author of Book: Quality of Life by Design Dr. Karra , that was the nicest way I’ve ever heard to stop promoting self interest and think of the team. I sincerely liked it… …Harold Cope Retired, Deputy Sheriff, State of Ohio, USA

7. It’s always a challenge to assess someone’s mind “There do seem to be links between some of the health conditions and creativity, and the notion that your brain can operate differently” ... Claudia Kalb Science journalist

8. Very Hard To Say

9. Balance / Moderation

10. 23,000 Human genes > 150 times DNA content comes from Bacteria Quit the place that is not fit for living Castor Oil ? What are the Input Variables? Think Right Speak Right Do Right

11. WHY QbD IS ESSENTIAL? Knowledge Design Control To Improve Manufacturing ‘by my people’ ……………………....What for?….………………… To Develop Quality Products ‘for my people’ …….....………......Why?………….…………….... Because WE CARE about the Quality-of-Life ‘of my people’ .......................Thank You…………………… Duty Conscious

12. The Fist Step – Team Work Ignore “I” “MINE” “Desire” (Selfishness) (Greed) Spiritual P E A C E Material Q U A L I T Y Think “We” “Us” “Ours” (Self- lessness ) (Oneness) Success Bliss Result Interactions Design Space

13. Second Step - Understand the Gap(s) “ QbD ” should start and end with the CUSTOMER (in Mind) ONLY - Quality, its intended purpose and Performance - Eliminate the seemingly inevitable variation (with OFAT or modeling - QbD ) Product Pain killer Kill the pain, not the patient Over promising and under serving

14. Courtsy : linda

15. Bench Mark Data from Benson & MaCab S.No Measure Pharma Industry Winning Pharma Industry World class factory 1 Stock turn 3-5 14 50 2 On-time delivery 60-80 % 97.4 % 99.6 % 3 Right First Time 85-95 % 96% 99.4 % 4 Over all Equipment Effectiveness (OEE) 30 % 74 % 92 % 5. Cycle time 720 hrs 48 hrs 8 hrs 6 Safety / 10 ^5 hrs 0.100 0.050 0.001

16. Current Status of ‘Cost of Poor Quality’ (CPQ) as % of sales – Indian Scenario. S.No Industry Sigma Value Ppm defects Yield % CPQ as % of Sales 1 Pharma 2 Sigma 3,08,537 69.2 25 – 30 2 Pharma 3 Sigma 66,807 93.3 20 – 25 3 Pharma 4 Sigma 6,210 99.4 12 – 18 4 Semiconductor 5 Sigma 233 99.98 4 – 8 5 Semiconductor 6 Sigma 3.4 99.99966 1 - 3

17. What is Fundamental ?

18. Scientific Data from Analytical testing must be reliable & trustworthy.

19. QbD Softwares built based on time-tested mathematical models will perhaps help Process Development in any field Manufacturing Efficiency Product Variability Process Capability Interactions among the input variables Help understand the Quality Spectrum - Scope, Quality, Time, Cost, Risk Easy to understand contour diagrams to extract the desired Design Space ??? Clinical Performance

20. Improve Quality of Life by Design Dr. K. V. Sarma . Author Quality of Life by Design

21. Conscious Design Multiplies the Quality of Life