ABSTRACT Introduction : Ankle injuries are a common problem that affects people of all ages and activity levels. The treatment for ankle injuries depends on the severity of the injury. More severe injuries may require surgery included ankle arthroplasty and physical therapy. The procedure is typically performed in patients with severe ankle arthritis or other conditions that have caused significant damage to the ankle joint. Methods: This study was traced from Google Scholar, Pubmed , Science Direct, and Elsevier Clinicalkey digital search pages systematically. This study included a randomize controlled trial that assessed patients who undergoes with ankle replacement compared with those who did not performed with ankle replacement. Quality assessment was carried out using Cochrane's Review Manager 5.4 application. Results: A total of 4 articles, including 443 patients, were analyzed. The meta-analysis showed significant improvement in AOFAS scores among patients in the experiment group (who underwent ankle replacement) compared with those in the control group (who did not undergo ankle replacement) [mean difference (MD) =−44.42, 95% confidence interval (CI): −47.02 to 41.82, Z=33.50, P<0.00001), VAS scores (MD =5.49, 95% CI: 5.01 to 5.96, Z=22.63, P<0.00001), FAAM scores (MD =−25.78, 95% CI: −31.27 to 20.29, Z=9.20, P<0.00001) compared to patients in the control group. Discussion: The quality of life, daily activities, and motor function recovery of patients with orthopedic ankle injuries were all improved with ankle arthroplasty. Conclusions: A nkle arthroplasty improves motor function, quality of life, and daily activities in patients with orthopedic ankle injuries. To validate the clinical application of ankle arthroplasty, future studies involving higher-quality research, larger sample sizes, and more outcome indicators are required. Keywords: Ankle arthroplasty, Ankle prosthesis, Motor function