Controlled released products in pharmacies.pptx

Controlled released products in pharmacies

1. Controlled released products in pharmacies Mohammed Aref Abdelrhman 1220469 Shady Adel Anwer 1220602

2. INTRODUCTION Controlled release drugs are designed to release their active ingredients at a predetermined rate to achieve a prolonged therapeutic effect, improving patient compliance and maintaining consistent drug levels in the bloodstream.

3. Glucophage® XR (metformin HCl extended-release) - This uses a dual hydrophilic polymer matrix system to control the release of metformin. After administration, fluid from the gastrointestinal tract causes the polymers to hydrate and swell, allowing drug release slowly by diffusion through the gel matrix over an extended period. Auvelity ® ER (dextromethorphan/bupropion extended-release) - This likely uses polymer matrix or coated pellet technology to extend the release of the drug combination over 24 hours compared to immediate-release formulations.

4. Lyrica® CR (pregabalin extended-release) - This uses an extended-release tablet formulation designed to provide controlled release of pregabalin over 24 hours after evening dosing, compared to the regular Lyrica capsules dosed 2-3 times daily . Toprol XL® (metoprolol succinate extended-release) - This contains metoprolol succinate in controlled-release pellets, where each pellet acts as a separate drug delivery unit designed to release the drug continuously over the 24-hour dosing interval .

5. Mirapex ER® (pramipexole extended-release) - The extended-release formulation likely uses polymer matrix technology or coated pellets to control pramipexole release over 24 hours compared to immediate-release. MS Contin (morphine sulfate controlled-release) - This uses polymer matrix technology to control the release of morphine over 12 or 24 hours compared to short-acting morphine products

6. Paxil CR (paroxetine hydrochloride controlled-release) - The controlled-release formulation extends paroxetine release using specialized polymer coatings or matrices. PENTASA® (mesalamine controlled-release) - This uses specialized coatings on mesalamine granules to delay release until the drug reaches the terminal ileum and colon .

7. Concerta (methylphenidate hydrochloride extended-release) - This uses a proprietary polymer-based oral delivery system (OROS) to control methylphenidate release over 12 hours. Oxycontin (oxycodone hydrochloride controlled-release) - This uses a controlled-release delivery system that forms a semi-rigid matrix to control oxycodone release over 12 hours