Cori's cycle

This Medicoapps Masterclass discusses about Cori cycle. Various Topics Discussed are given below
Cori cycle Various Steps
Significance of Cori’s Cycle
Exam points of Cori’s Cylce

1. Cori Cycle [
Flowchart
]

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Cori cycle (Lactic acid cycle)
Glucose
Glucose
2-Pyruvate
2-Lactate
2-Lactate
2-Lactate2-Pyruvate
Glucose
Gluconeogenesis
Glycolysis
6 ATP
2 ATP
Blood
Muscle
Liver
In normal state
, muscular activities require ATP, from glucose wwwwconverted to pyruvate (NAD
+
wwwwNADH)
In low O
2state
, as in intensive exercise or hypoxic condition- mo re ATPs requires
Glycogen
Glycogenolysis
NADH NAD
+
LDH
Anerobic
metabolism
Lactic acid
fermentation
NADH
NAD
+

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Significance
Cori cycle prevents, lactate accumulation in the mu scles Cori cycle is important in producing ATP in low oxy gen conditions. Cori cycle takes place in
liver, blood and muscle
Cori cycle utilizes, lactate from muscle for glucon eogenesis. Cori cycle is pathway that links anaerobic glycolys is in the muscle to gluconeogenesis in the liver

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Exam points
Cori cycle is also called as
lactic acid cycle or glucose – lactate cycle
Cori cycle occurs
in muscle, blood and liver.
Pyruvate is converted to lactate in the presence of
lactate dehydrogenase enzyme
Cori cycle gains 2 ATP and loss of 6 ATP Glucose cannot be synthesized in muscle because there are no gluconeogenesis enzymes Cori cycle is pathway that links anaerobic glycolys is in the muscle to gluconeogenesis in the liver

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Brain Teaser
Cori cycle takes place in muscle, blood and liver!! TRUE/ FALSE??