cosmeceuticals by aaqib

Cosmeceuticals have become the fastest-growing segment of the personal care industry. About 25 years ago Dr. Albert Kligman of the University of Pennsylvania originally coined the term ‘cosmeceutical’, describing a hybrid category of products found on the spectrum between drugs and cosmetics that exert a pharmaceutical therapeutic benefit but not necessarily a biological therapeutic benefit.

1. Presented By :
Muhammad Aaqib
Guided By :
Asst. Prof. Mr. Avinash Hatkar
SHRI R.D. BHAKT COLLEGE OF PHARMACY, JALNA

2. Introduction
TheFood,drug,andCosmeticActdefinescosmeticsbytheir
intendeduse,asarticlesintendedtoberubbed,poured,
sprinkledorsprayedon,introducedinto,orotherwiseapplied
tothehumanbodyforcleansing,beautifying,promoting
attractiveness,oralteringtheappearance.
Amongtheproductsincludedinthirddefinitionareskin
moisturizers,perfumes,lipsticks,fingernailpolishes,
deodorants,aswellasanymaterialintendedforuseasa
componentofacosmeticproduct.
Thesecosmeceuticals,servingasabridgebetweenpersonal
careproductsandpharmaceuticals,havebeendeveloped
specificallyfortheirmedicinalandcosmeticsbenefits.

3. Review Literatue
 Y.MadhusudanRao
Cosmeceuticalshavebecomethefastest-growingsegmentofthepersonalcare
industry.About25yearsagoDr.AlbertKligmanoftheUniversityofPennsylvania
originallycoinedtheterm‘cosmeceutical’,describingahybridcategoryof
productsfoundonthespectrumbetweendrugsandcosmeticsthatexerta
pharmaceuticaltherapeuticbenefitbutnotnecessarilyabiologicaltherapeutic
benefit.1
 SINGHALMUKUL
Cosmeceuticalsisthemergingofcosmeticswithpharmaceuticalindustry.These
daysnumberofcosmeceuticalproductshavebeenintroducedintothemarketwith
enhancedefficacy.Moisturizers,sunscreen,pigmentlightenerandother
formulationshavebeenrenovatedtoimprovisedformsbyadditionofdruglike
ingredientsforbetterresults.Cosmeceuticalscontributemajorlytothecosmetic
industry.Althoughtheeffectsmaybesmall,theseproductshoweverimprovethe
skinfeelandappearancewithcontinueduseoveraperiodoftime;thustherelies
greatopportunitytoexplorethisavenue.Thepresenttextaimstohighlightthe
bloomingskincosmeceuticalsindustrythatofferslimitlesspossibilitiesfor
identifyingnewfunctionalmaterialsaswellasexploretheexistingclassesof
compounds.

4. Skin Cosmeceuticals
 Cosmetics and skin care products are the part of
everyday grooming. Protecting and preserving the skin is essential to
good health.
 These products improve the functioning/texture of the
skin by encouraging collagen growth by combating harmful effects of free
radicles, thus maintain keratin structure in good condition and making the
skin healthier.
 OLAY vitamin line, which includes vitamins A,C,D,E,
selenium, and Iycopene, pycnogenol plus zinc and copper, is a well-known
skin care line.

5. Sunscreens
 Sunscreen is the single most important
step to maintain healthy, youthful-looking skin
 Physical agents, or sun blocks, act as
barriers, which reflect or scatter radiation/sun
blocks, act as barriers, which reflect or scatter
radiation.
 Some commercially available sunscreens
are Benzophenone-8.

6. Moisturizers
 Moisturizers function to smooth out the age
lines, help brighten, and tone the delicate skin.
It also helps to make the skin surface smooth by it
Smooth by its lubrication action.
They maintain moisture content and prevent the
dry contion of the skin

7. Bleaching agents
 Bleaching agents are used for
bleaching/fading the various marks and act to
block the formation of the skin pigment melanin.
 As with any bleaching agent, aggressive
exfoliation, and sun protection are necessary for
good results.
 Hydroquinone is the most commonly
used agent

8. HAIR COSMECEUTICALS
 Cosmetics for the treatment of hair are applied
topically to the scalp and hair.
 A hair cosmeceutical product includes -
conditioning agents, special care ingredients, and hair growth
stimulants.
 Conditioning agents are intended to impart
softness and gloss to reduce flyaway and to enhance
disentangling facility.
 A minoxidil-related compound is a cosmetic
agent with claim of acting as a topical hair growth stimulant

9. Other cosmeceuticals
 These products are specially formulated
with ingredients that work from the inside out by
interacting with the cells under the skin's surface-without
irritating the eyes.
 There are numerous cosmeceutical eye
creams that nourish the skin with natural emollients and
beneficial nutrients.
 The eye wrinkle cream helps forestall the
signs of aging

10. Drugs used in
cosmeceuticals
Alpha Hydroxy Acids
Antioxidants
Botanicals

11. Alpha Hydroxy Acids (AHAs)
 AHAs improve skin texture and
reduce the signs of aging.
Examples include:
Citric acid
Glycolic acid
Lactic acid
Malic acid
Pyruvic acid
Tartaric acid

12. Antioxidant
 Antioxidants reduce free-radical
damage, thereby preventing impairment at
thecellular level.
 L-ascorbic Acid (Vitamin C)
Reduce both pigmentation and inflammation.
 Niacinamide (Vitamin B3).
Reducing transepidermal water loss.
 α-tocopherol (Vitamin E).
Reduce sunburn cells after UV exposure, act as a
humectant.

13. Botanicals
 Botanicals comprise the largest category
of cosmeceutical
 Green Tea Extract.
Potent suppressors of carcinogenic activity
 Ferulic Acid.
Photo protection to skin
 Grape Seed Extract.
Speed wound contraction and closure

14. Cyclodextrins in
cosmeceuticals
 Cyclodextrins are used in the
preparation of cosmetics
 Use of "Empty" Cyclodextrins
1.Scrubbing Particles.
2.Entrapement of Unpleasnt Odors.
a. Mouth Odors
b. Body Odors

15. Common sources of
Cosmeceuticals
IngredientPurported actionSource
Vitamins Anti-oxidant Vit A,C and D
Alpha
hydroxy acids
Exfoliates and
improves circulation
Fruit acids(glycolic
acid,lactic acid,citric
acid)
Aloe Vera Softens skin Aloe vera
Cucumber Cools,refreshes and
tightens pores
Cucumber
Panthenol Builds moisture and
soothes irritation
Pro-vitamin b5
PycnogenolAntiageing agentGrape seed extract
Beta-
Carotene
Minimizes lipid
peroxidation
and cellular
antioxidant
Carrots and tomatoes

16. Applications
 APPLICATION OF MICROCAPSULES IN
COSMETICS:
 A. Skin-Care Products
a.UV Protective Creams
b.Cleansing Creams
 B. Hair Products
a. Hair Creams and Ointments
b. Shampoos
 C. Cosmetic colorant Compositions
a. Lipsticks
b. Face Powders

17. Conclusion
 The future promises increasingly
sophisticated formulations for cosmetics and skin-
care products.
 Cosmetic companies are finding ways to
deliver small-dose ingredients that do not require
medical regulations and to introduce steroids and
hormones in to lip balms, which would result in
production of cosmeceuticals that could help to
improve body mass, nail, and hair growth.
 The trend towards therapeutic cosmetics
is sure to result in the need to obtain a better
understanding of modern ingredients and
assessment techniques.

18. References
1)GasparLR,CamposPM.Photostabilityandefficacystudiesof
topicalformulationscontainingUVfilterscombinationand
vitaminsA,C,andE.IntJPharm343(1-2):181-9.
2)BissettDL,MiyamotoK,SunP,etal.Topicalniacinamidereduces
yellowing,wrinkling,redblotchiness,andhyperpigmentedspots
inagingfacialskin.IntJCosmetSci26(5):231-8(2004Oct).
3)BissettOL,OblongJE,BergeCa.Niacinamide:ABvitaminthat
improvesagingfacialskinappearance.DermatolSurg31(7Pt
2):860-5(2005Jul).
4)KatayamaK,Armendariz-BorundaJ,RaghowR,etal.A
pentapeptidefromtypeIprocollagenpromotesextracellular
matrixproduction.JBiolChern268(14):9941-4(1993May)
5)RobinsonLR,FitzgeraldNC,DoughtyDO,etal.Topical
palmitoylpentapeptideprovidesimprovementinphotoaged
humanfacialskin.IntJCosmetSci27(3):155-60(2005Jun).

19. THANK YOU
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