Cosolvency

Solubility enhancement technique

1. School Of Pharmacy SRTMU Nanded PRESENTED BY: RAJESH LAXMAN RAUT M.Pharm I (QA) GUIDED BY: Mr. G. CHATE SIR Ast . PROFESSOR CO-SOLVENCY

2. Content Introduction Solubility Definition Reasons For Solubility Enhancement Techniques for solubility enhancement Cosolvancy Mechanism of cosolvency Advantages and disadvantages

3. Introduction Solubility, the phenomenon of dissolution of solute in solvent to give a homogeneous system, it is one of the important parameter to achieve desired concentration of drug in systemic circulation for desired pharmacological response. Any drug to be absorbed must be present in the form of solution at the site of absorption Therefore various technique are used for the enhancement of the solubility of poorly soluble drugs

4. Solubility Definition: The amount of substance that passes into the solution in order to establish equilibrium at constant temperature and pressure to produce a saturated solution.

5. Need of solubility enhancement Oral administration of drug is the most commonly used drug delivery route. The oral bioavailability is highly dependant on solubility. Poorly water soluble drugs having slow drug absorption leads to inadequate and variable bioavailability. It will cause gastrointestinal mucosal toxicities. Therefore just to improve the bioavailability of a drug one has to increase the solubility.

6. Solubility Enhancement Techniques

7. Cosolvancy The solubility of a poorly water soluble drug can be increased by the addition of water miscible solvent in which the drug has a good solubility This whole procedure is known as cosolvency and the solvent is called cosolvant Cosolvents are mixture of water and one or more water miscible solvent use to create a solution with enhance solubility for a poorly water soluble drugs.

8. Characteristics of Cosolvents

9. Widely used cosolvents

10. Discussion Parenteral formulation may require addition of water or a dilution step before administration. Dimethyl sulphoxide (DMSO) and Dimethyl acetamide (DMA) have been widely used as cosolvents b’coz of there large solubilisation capacity for poorly soluble drug and there relatively low toxicities A blend of propylene glycol and water is use to improve the solubility of clotrimoxazole in oral solution and paracetamol is formulated as elixir by use of alcohol and propylene glycol

11. 17/02/2017

12. 17/02/2017