creams.pptx

Pharmaceutical Creams

1. Creams Name: Shaban Nazir Qadri Roll no: 40

2. Learning Objectives What is cream and its pharmaceutical application Classification and method of preparation Packaging , labeling and storage

3. Definition pharmaceutical creams are the viscous ,semisolid emulsified preparations containing medicinal agent dissolved or dispersed in either an oil in water or water in oil emulsion or in another type of water washable base for external application. Classification of cream on the basis of function: cleansing and cold cream Foundation and vanishing cream Night and massage cream Head and body cream All purpose and general cream

4. Types of cream on the basis of phase Water in oil (W/O) Its is a mixture in which an oily medicine is dispersed in water or other liquid these are used to prevent evaporation of moisture from the surface of the skin Example butter cream ,cold cream Oil in water (O/W) It is a mixture in which an oily medicine is dispersed in water or other liquid These provide cooling effect on evaporation Example vanishing cream

5. Bases used for creams Oleaginous bases Absorption bases Water removable bases Water soluble bases

6. Preparation method of creams The basic method of preparation of creams fusion method. Incorporation method Fusion method: warm both the oil and the liquid phase to about 60 ℃ mix the both phases stir until cold Incorporation method: Is used when a drug is to be added to an already prepared ointment or cream system when the vehicle is heat liable

7. Pharmaceutical application of creams The provision of barrier to protect the skin To aid in the retention of moisture(especially water in oil creams ) Cleansing Emollient effects As a vehicle for drug substances such as local anesthetic ,anti- inflamatory (NSAIDS and Corticosteroids), hormones ,antibiotics ,antifungal or counter irritants.

8. Advantages and Disadvantages Advantages have smooth consistency Less greasy and easy to apl No visible evidence of its presence. Have soothing action on inflamed area Have better contact with skin. More stable than emulsion Disadvantages Burning Irritation Stinging Acne Dryness Unusual hair growth

9. Packaging and Containers Containers that mostly used are Wide mouth jars Collapsible metals Flexible plastic tubes Aluminum tubes All products should be in air tight containers to prevent water loss and gain Aluminum tubes should be used when a product has a ph less then 6.5

10. Filling Filling is done by two methods Hand filling Mechanical filling Storage Creams must be stored in a cool place to protect against product separation in heat Labeling: Labeling instruction include “ for external use only” Shelf life : An expiry date of 3-4 weeks is a appropriate for creams that are freshly prepared