CRP test & ESR test

Serum levels of C-reactive Protein test (CRP)
erythrocyte sedimentation rate test (ESR)
how to perform test and results meaning with their significant in inflammation

1. Define (ESR) and (CRP) and Explain their significance in inflammation

2. In this test, a tall, thin tube holds a sample of your blood. The speed at which the red blood cells fall to the bottom of the tube is measured. E rythrocyte  S edimentation  R ate (ESR) Is a test that helps the doctor determine whether the patient is experiencing inflammation or not. The test mainly measures the plasma viscosity by assessing the tendency for red blood cells to aggregate and ‘fall’ through the variably viscous plasma.

3. plasma viscosity and speed?

4. ↑ (SPEED)

5. Inflammation can cause abnormal proteins to appear in your blood. These  proteins  cause your red blood cells to clump together. This makes the red blood cells  fall more quickly . The significance of ESR in inflammation : ↑ (SPEED)

6. This test involves a blood draw. First, the skin directly over your vein is cleaned. Then, a needle is inserted to collect your blood . After collecting your blood, the needle will be removed and the puncture site will be covered to stop any bleeding. It should take only a minute or two. The ESR Test

7. ESR test results are measured in mm/hr, or millimeters per hour. The following are considered normal ESR test results: • Women under age 50  should have an ESR under 20 mm/hr. • Men under age 50  should have an ESR under 15 mm/hr. • Women over age 50  should have an ESR under 30 mm/hr. • Men over age 50  should have an ESR under 20 mm/hr. • Newborns  should have an ESR under 2 mm/hr. • Children who haven’t reached puberty yet  should have an ESR between 3 and 13 mm/hr. Normal ESR Test Results (SPEED)

8. An abnormal ESR result doesn’t diagnose any particular disease. It just identifies any inflammation in your body. This test is  NOT always reliable or meaningful . Many factors, such as age or medication use, can alter your results. What Do Abnormal ESR Test Results Mean?

9. C - r eactive  P rotein (CRP)

10. (CRP) is a blood test  marker  for inflammation in the body. CRP is a protein produced by the liver in response to inflammation  and its level is measured by testing the blood. A high level of CRP in the blood is a marker of inflammation . It can be caused by a wide variety of conditions, from infection to cancer. C - r eactive  P rotein (CRP)

11. CRP is very common

12. What does CRP results mean ? CRP tests the amount of proteins in blood

13. C-reactive protein has an important role in many parts of the inflammatory process. It is involved in the innate immune response by attaching to microorganisms and damaged cellular components via phosphocholine. — This leads to complement activation and phagocytosis. The significance of CRP in inflammation:

14. THANK YOU

15. REFERENCES Osei-Bimpong A, Meek JH, Lewis SM. ESR or CRP? A comparison of their clinical utility. Hematology2007;12:353-7. [PubMed] Feldman M, Aziz B, Kang GN, Opondo MA, Belz RK, Sellers C. C-reactive protein and erythrocyte sedimentation rate discordance: frequency and causes in adults. Transl Res 2013;161:37-43. [PubMed]