CUTTING EDGE IN THE TOPICAL DELIVERY.pptx

INNOVATION IN TOPICAL DRUG DELIVERY

1. Cutting-edge Innovations in Topical Drug Delivery Systems: A Contemporary Overview Overcoming Barriers and Enhancing Therapeutic Outcomes DR. PRAKASH S. GOUDANAVAR Professor and Vice Principal, Department of Pharmaceutics Sri Adichunchanagiri College of Pharmacy Adichunchanagiri University

2. Understanding Topical Drug Delivery Systems Topical drug delivery involves the administration of medications via the body's external surfaces, primarily the skin, to achieve local or systemic therapeutic effects. This route offers several advantages, including non-invasiveness, ease of application, and potential for targeted delivery. As a result, topical formulations are widely used in dermatology, cosmetology, pain management, and beyond.

3. Significance of Innovation In recent years, there has been a growing emphasis on innovation within the field of topical drug delivery. This focus stems from the recognition of the limitations of traditional formulations and the desire to overcome these challenges through novel approaches. By embracing innovation, researchers and practitioners aim to enhance the efficacy, safety, and patient compliance of topical treatments.

4. Improving Penetration Enhancing Stability & Enabling Controlled Release Personalization Key Objectives of Innovation in Transdermal

5. Challenges in Traditional Topical Drug Delivery Limited Penetration Depth Lack of Sustained Release Variability in Drug Absorption Risk of Skin Irritation & Formulation Challenges Traditional Topical Drug Delivery

6. Strategies in Enhancing Drug Stability and Efficacy Encapsulation Techniques Temperature-sensitive Carriers pH-responsive Formulations Encapsulating drugs in nanoparticles, liposomes, or polymeric carriers protects them from degradation and enhances stability. Formulations that respond to pH changes can release drugs in a controlled manner , enhancing efficacy and minimizing side effects. Carriers that release drugs in response to temperature changes can provide targeted and controlled drug delivery. pH-responsive Formulations

7. Controlled release Strategies Hydrogel Hydrogels can swell and release drugs in a controlled manner, providing sustained therapeutic effects. Transdermal Patches Transdermal patches can deliver drugs at a controlled rate over extended periods, reducing the need for frequent application Microemulsions Microemulsions are thermodynamically stable systems that enhance drug solubility and provide controlled release. 3D Printing Technology Patient-specific Drug Combinations Personalized Topical Treatments Controlled Release Strategies & personalized topical treatments

8. Advanced Transdermal Delivery Routes

9. Regulatory Considerations 1. FDA and EMA Guidelines Regulatory agencies like the FDA and EMA provide guidelines for the safety and efficacy of topical drug delivery systems. 2. Safety and Efficacy Assessments Innovative delivery systems must undergo rigorous testing to ensure they meet regulatory standards.

10. Future Perspectives 1. Integration of Artificial Intelligence AI can aid in the design and optimization of topical formulations, predicting outcomes and improving efficacy. 2. Smart Wearable Devices Wearable devices can monitor drug delivery in real-time, providing feedback and optimizing treatment.

11. New smart wearable microneedle drug device concept could transform healthcare delivery

12. Smart Hydrogel for Topical drug delivery systems Introduction Smart hydrogels are advanced materials designed for enhanced wound healing. They exhibit responsive behaviors to external stimuli such as temperature, pH, and light, enabling controlled release of therapeutic agents. Key Features Responsive Nature : Adjusts its properties in response to environmental changes, optimizing the healing process. Moisture Regulation : Maintains an optimal moist environment, which is crucial for faster wound healing. Controlled Drug Release : Delivers medications like antibiotics and growth factors directly to the wound site over time. Biocompatibility : Non-toxic and compatible with body tissues, reducing the risk of adverse reactions.

13. Multifunctional Hydrogel Nanocomposites for Biomedical Applications

14. Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and  Malva sylvestris  extract for a better diabetic wound healing

15. Preparation of neomycin sulphate nanofibers (NS-NF) ultrasonication for 30 min. Electrospinning Stirred for 7 hours at 80 °C 5 ml syringe Needle- having 1.23 mm outer diameter, 0.83 mm internal diameter Nanofibers

16. MS-NS-NF

17. v 6.0 (2022)  Impact Factor Q1  Impact Factor Best Quartile 6.5 (2022)  5 year IF 8.7 (2022)   CiteScore (Scopus) Q1   CiteScore Best Quartile 1.053 (2022)  SNIP

18. Preparation of nanocomposites Diffusion loading method [A] Synthesis of Chitosan- L-cysteine conjugates forming Chitosan (TCS) : [B] Preparation of TCS-PEG/MMT composites: [C] Antiretrovirals loading on TCS-PEG/MMT composites

19. Swelling degree SEM Drug Release study

20. 0.8 Impact Factor Q3  Impact Factor Best Quartile 1.2   CiteScore (Scopus)

21. QbD assisted formulation design and optimization of thiol pectin based Polyethyleneglycol and Montmorillonite(PEG/MMT) nanocomposite films of neomycin sulphate for wound healing

22. Pectin was thiolated (TFP) followed by the formulation of neomycin sulphate nanocomposites using polyethylene glycol and montmorillonite (PEG/MMT) to accelerate wound healing. Optimized nanocomposite formulation was further formulated into nanocomposite film (ONCF) and evaluated for mechanical properties, drug release, cytotoxic, and in vitro wound healing capabilities. OCNF had no cytotoxic effects, as evident from the more than 90%survival rate of C6 glioma cells. In vitro wound, healing activities prove that composite-to-film conversion will be responsible for most antioxidant activity. In vivo wound healing and histomorphometry studies demonstrate the formulation's efficacy in wound healing.

23. 5 .04 Impact Factor Q1  Impact Factor Best Quartile 7.6   CiteScore (Scopus)

24. Liposomes loaded Microneedles Preparation of Bosentan Monohydrate Loaded Liposomes Preparation of the Master mold by 3D printing technology (SLA) Initially the 3d CAD model of the master mold was designed using software(Figure2), The 3D model was further sliced and exported in standard triangle language(STL) format and fabricated for master mold microneedles arrays with standard resin by using SLA 3D Printing technology( Crealty Halot Mage, China). 3D CAD Model of the master mold and SLA 3D Printed mold

25. Preparation of dissolving microneedle array patches The PDMS molds were filled withPVA,PVP-K30 and PEG-400 mixture and Bosentan Monohydrate Loaded liposomes, all in the defined proportions. After that, the molds were put onto the centrifuge ’ s plate rotor and centrifuged for 45 min at 3000 rpm. After centrifugation, the mold was kept in an isolation chamber (at room temperature and 45%RH) for 24 hours for drying. Two step casting method for the preparation of microneedles Skin pricing image of rat skin

26. VGST Grant Novel semi-synthetic bicephalous hetero lipid nanoparticulate system for m- rna delivery in the treatment of metastatic breast cancer. Final formulation Transdermal Patch ????