Describe the mechanism of action, indications, adverse effects, and contraindication of clomiphene

Describe the mechanism of action, indications, adverse effects, and contraindication of clomiphene

1. Objectives
Describe the mechanism of action, indications, adverse
effects, and contraindication of clomiphene

2. •Non steroidal compound
•Partial agonist at estrogen receptor.
•First drug of choice in induction of ovulation.

3. Binds to hypothalamic and pituitary estrogen receptors
Blocks inhibitory feedback of estrogen
Increased release of GnRH
Increased FSH and LH
Ovulation occurs

4. •Infertility associated with anovulatory cycles.
•Aid in in-vitro fertilization
•Oligozoospermia

5. •Hot flushes
•Visual symptoms
•Ovarian enlargement
•Multiple pregnancy
•Increased risk of Ovarian carcinoma
•Headache, Nausea, Vomiting, Constipation
•Reversible hair loss
•Weight gain
•Heavy Menses

6. •Patients with enlarged ovaries
•Patients who have visual symptoms
associated with clomiphene therapy
•Chronic liver disease

7. •Basic and clinical pharmacology, Katzung, 12
th
edition, 2012