Diamond_Concept_Presenuntuk UItation_v2.pptx

presentasi sederhana

1. Diamond Concept in Bone Regeneration An Overview from Recent Studies

2. Overview of Diamond Concept The Diamond Concept is a multidimensional approach to bone regeneration, integrating key biological and mechanical factors to optimize healing. It was initially proposed to improve bone healing outcomes by addressing both biological and biomechanical components. • Four key factors: Osteogenic cells, Osteoinductive mediators, Osteoconductive scaffolds, and Mechanical stability. • Sometimes includes a fifth factor: Vascularization.

3. Diamond Concept in Chitosan-based Scaffolds Agnes et al. (2023) discuss the implementation of the Diamond Concept in bone tissue engineering, particularly using cross-linked chitosan-based scaffolds for non-load bearing bones. • Key elements: Osteogenic cells, Osteoconductive scaffolds, Osteoinductive mediators, Mechanical environment. • Chitosan-based scaffolds are designed to support bone regeneration by providing structural and biological support.

4. Diamond Concept in 3D Bioprinting Osypko et al. (2023) apply the Diamond Concept to 3D bioprinting in regenerative dentistry. • Four key factors: Osteogenic cells, Osteoconductive scaffolds, Growth factors, Mechanical stabilization. • Fifth factor: Vascularization is crucial for the integration and function of bioprinted tissues.

5. Diamond Concept in Fracture Healing Giannoudis et al. (2007) introduced the Diamond Concept as an advancement of the traditional triangular model in fracture healing. The diamond model includes an additional focus on mechanical stability. • Key factors: Osteogenic cells, Osteoconductive scaffolds, Osteoinductive mediators, Mechanical stability. • Mechanical stability is vital for the formation of a callus and the successful healing of bone fractures.

6. Conclusion The Diamond Concept is a comprehensive framework that integrates biological and mechanical elements for successful bone regeneration and fracture healing. It has been adapted in various fields, including tissue engineering and regenerative medicine. • Future directions include exploring advanced materials and techniques, such as 3D bioprinting, to further improve bone healing.