DIAPOEje_Desarrollo_Dinámico_Neurofarmaco.pptx

GuillermoRivera2 10 views 16 slides Aug 29, 2025

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Desarrollo dinámico

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Added: Aug 29, 2025

Slides: 16 pages

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Neurofarmacología Eje transversal Desarrollo Dinámico

Common architecture of iGluRs. (A) iGluR subunit polypeptide chain (B) subunit topology (C) and (D) Structures of distinct subunit conformations adopted in homomeric GluA2 receptors (E) Structure of GluA2 homomer (F) N-terminal domain NTD mediates receptor assembly, trafficking and functional regulation (G) agonist binding domain ABD harbors binding sites for agonists, competitive antagonists, and some allosteric modulators (H) transmembrane domain TMD layers

(A) Homomeric GluA2 AMPA receptor with competitive antagonist (ZK) (B) Homomeric GluK2 kainate receptor with agonist (MG) (C) GluN1/2B NMDA receptor with Glu and Gly and the allosteric inhibitor ifenprodil (D) Homomeric GluD1 receptor