Digestive system

In the human digestive system, the process of digestion has many stages, the first of which starts in the mouth (oral cavity). Digestion involves the breakdown of food into smaller and smaller components which can be absorbed and assimilated into the body. The secretion of saliva helps to produce a bolus which can be swallowed to pass down the oesophagus and into the stomach.

1. Digestive System Sharif Tanvir Executive, PMD Concord Pharmaceuticals Ltd .

2. Digestive System The human gastrointestinal tract, or GI tract, or GIT is an organ system responsible for consuming and digesting foodstuffs, absorbing nutrients, and expelling waste.

3. Digestive System GI tract includes all structures between the mouth and the anus. On the other hand, the digestive system is a broader term that includes other structures, including the digestive organs and their accessories

4. Part of Digestive System

5. Functions of the GI system Motility: movement through the GI tract Digestion: breakdown of food or chyme Secretion and absorption: across and epithelial layer either into the GI tract (secretion) or into blood (absorption) Storage and elimination

6. Parts of the stomach Fundus body pyloric region (pyloric sphincter) material passed from the stomach to the small intestine is called the chyme . The gastric glands of the stomach contain several types of cells:

7. Parts of the stomach

8. Antiulcerants Esmax ( Esomeprazole ) 20 mg & 40 mg Capsule 20 mg Tablet Pramax ( Pantoprazole ) 20 mg & 40 mg Tablet Opmax ( Omeprazole ) 20 mg & 40 mg Capsule

9. H 2 Receptor Blocker Recodin 150 Tablet (Ranitidine)

10. Physiology of Gastric Acid Secretion

11. Indications of PPIs 1. Gastro esophageal reflux disease: ( GERD)  It is a chronic symptom of mucosal damage caused by stomach acid coming up from the stomach  into the  esophagus tube . 2. Heart burn: It is a painful burning feeling in the chest or throat . It happens when stomach acid backs up into esophagus tube that carries food from mouth to stomach. 3. Zollinger -Ellison syndrome Zollinger -Ellison syndrome is a complex condition in which one or more tumors form in your pancreas or the upper part of your small intestine (duodenum). 4. NSIDs induced ulcer

12. Indications of PPIs 5. Gastric Ulcer Peptic ulcers are open sores that develop on the inside lining of your esophagus, stomach and the upper portion of your small intestine . The most common symptom of a peptic ulcer is abdominal pain.

13. Gastro- Prokinetic Agent Doagut Tablet 10 mg ( Domperidone ) Doagut Tablet Suspension 5mg/5ml ( Domperidone )

14. Mechanism of Action Domperidone is a peripheral dopamine (D2) and (D3) receptor antagonist. It provides relief from nausea by blocking receptors at the chemo-receptor trigger zone (a location in the nervous system that registers nausea) at the floor of the fourth ventricle (a location near the brain). 

15. Indications Nausea & Vomiting Non-ulcer dyspepsia Reflux Esophagitis and Gastritis Functional Dyspepsia Migraine

16. Thank You…!!!