Digitalis nikku ppt

Drug presentation on Digitalis drug

1. SUMANDEEP NURSING COLLEGE DRUG PRESENTATION ON DIGITALIS PRESENTED BY NIKHIL VAISHNAV M.Sc. Nursing Final year

2. CARDIAC GLYCOSIDE

3. ACTIONS On CVs: Digitalis increase oxygen consumption of heart to normal. It increases energy utilization, increases myocardial contraction. Decreases venous return. Conduction system: Digitalis depresses the conduction system by direct action.

4. DIGITALIS A drug prepared from the dried leaves of foxgloves and containing substances (notably digoxin and digitoxin) that stimulate the heart muscle. The term digitalis is also used for drug preparations that contain cardiac glycosides, particularly one called digoxin, extracted from various plants of this genus.

5. DIGOXIN Generic name: Digoxin. Brand name: Lanoxin, Lanoxicaps, Cardoxin, Digitek. It is a cardiotonic glycoside obtained mainly from Digitalis lanata. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation.

6. It is excreted via kidneys. Dosage: In Adults- oral solution 0.05mg/mL , Injectable solution- 0.1mg/ mL.

7. ACTION Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. The sodium calcium exchanger (NCX)in turn tries to extrude the sodium and in so doing, pumps in more calcium . Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin ). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

8. NURSING CONSIDERATION

9. DIGITOXIN

10. MECHANISM OF ACTION

11. Indications: Congestive heart failure , atrial flutter, atrial tachycardia, atrial fibrillation. Dosage: Adult and child age 12 years and above , orally 1.2 to1.6 mg per day in divided dose. Child 1 to 2 year age 0.04 mg per kg weight. Contraindications: Hypersensitivity, hypokalemia , pregnancy, lactation, hepatic disease, A.V. block, ventricular tachycardia.

12. Side effect: Hypersensitivity, hypokalaemia, pregnancy, lactation, hepatic disease, A.V. block, ventricular tachycardia. Nursing care: To monitor drug level during therapy . To monitor apical pulse rate, blood pressure during therapy . To carry out blood investigations, BUN, Creatinine, ALT,AST, bilirubin . To advice patient to take banana, orange juice in diet as they are rich source of potassium.

13. DIGITALIS TOXICITY

14. TREATMENT OF DIGITALIS TOXICITY Digoxin immune fab or Digoxin-specific antibody is an antidote for overdose of digoxin. It works by binding to the digoxin, rendering it unable to bind to its action sites on target cells. It is made from immunoglobulin fragments from sheep

15. DIGOXIN IMMUNE FAB Action: Digoxin immune FAB do not allow digoxin to bind to the sites of action and reverse digoxin toxicity. Indications: Digoxin or digitoxin toxicity. Contraindications: Hypersensitivity, mild digoxin toxicity, children , pregnancy, lactation . Side effects: Facial swelling, redness, rapid respiration rate, low cardiac output.

16. NURSING CARE